轮状病毒疫苗的研究进展

被引:2
作者
吕华
严有望
机构
[1] 湖北省荆州市荆州区卫生局防保科
关键词
D O I
暂无
中图分类号
R186 [预防接种、计划免疫、药物预防];
学科分类号
100401 [流行病与卫生统计学];
摘要
<正>轮状病毒是引起5岁以下儿童严重脱水性腹泻的主要原因之一。据世界卫生组织(WHO)估计,2008年全球有45.3万儿童死于轮状病毒胃肠炎(RVGE),约占全部死亡儿童的5%,5岁以下儿童的死亡率为86/10万。约90%的轮状病毒死亡者发生在亚非等经济、卫生欠发达国家。轮状病毒疫苗免疫前,全球每年有超过200万儿童因轮状病毒感染住院[1]。预防轮状病毒腹泻除早期母乳喂养、勤洗手、改善环境和水供应、治疗患者等措施外,免疫接种是特异性的有效措施。20世纪70年代末开始研究轮状病毒疫苗,1998年第一种轮状病毒疫苗即口服恒河猴4价轮状病毒活疫苗(RRV-
引用
收藏
相关论文
共 6 条
[1]
Rotavirus vaccines WHO position paper - January 2013/Vaccins antirotavirus Note de synthèse de l'OMS.[J].Anonymous.Weekly Epidemiological Record.2013, 5
[2]
Rotavirus vaccine RIX4414 efficacy sustained during the third year of life: A randomized clinical trial in an Asian population [J].
Phua, Kong Boo ;
Lim, Fong Seng ;
Lau, Yu Lung ;
Nelson, Edmund Anthony Severn ;
Huang, Li Min ;
Quak, Seng Hock ;
Lee, Bee Wah ;
van Doorn, Leen Jan ;
Teoh, Yee Leong ;
Tang, Haiwen ;
Suryakiran, P. V. ;
Smolenov, Igor V. ;
Bock, Hans L. ;
Han, Htay Htay .
VACCINE, 2012, 30 (30) :4552-4557
[3]
Efficacy and immunogenicity of two or three dose rotavirus-vaccine regimen in South African children over two consecutive rotavirus-seasons: A randomized; double-blind; placebo-controlled trial.[J].S.A. Madhi;M. Kirsten;C. Louw;P. Bos;S. Aspinall;A. Bouckenooghe;K.M. Neuzil;A.D. Steele.Vaccine.2011,
[4]
Intussusception following rotavirus vaccine administration: Post-marketing surveillance in the National Immunization Program in Australia [J].
Buttery, J. P. ;
Danchin, M. H. ;
Lee, K. J. ;
Carlin, J. B. ;
McIntyre, P. B. ;
Elliott, E. J. ;
Booy, R. ;
Bines, J. E. .
VACCINE, 2011, 29 (16) :3061-3066
[5]
Efficacy of human rotavirus vaccine against rotavirus gastroenteritis during the first 2 years of life in European infants: randomised, double-blind controlled study [J].
Vesikari, T. ;
Karvonen, A. ;
Prymula, R. ;
Schuster, V. ;
Tejedor, J. C. ;
Cohen, R. ;
Meurice, F. ;
Han, H. H. ;
Damaso, S. ;
Bouckenooghe, A. .
LANCET, 2007, 370 (9601) :1757-1763
[6]
口服轮状病毒活疫苗安全性和免疫原性观察 [J].
龚富强 ;
朱秀兰 .
微生物学免疫学进展, 2005, (03) :10-11