低分子肝素的新作用—抗炎/抗细胞粘附机制的研究进展

被引：43

作者：

李丹丹 ^{[1
]}

孟建中 ^{[2
]}

焦炳华 ^{[1
]}

机构：

[1] 第二军医大学生物化学与分子生物学教研室

[2] 济南军区总医院

来源：

生物医学工程研究 | 2008年 / 02期

关键词：

低分子肝素; 炎症; 内皮细胞; 氧自由基; 细胞间粘附分子;

D O I：

10.19529/j.cnki.1672-6278.2008.02.017

中图分类号：

R96 [药理学];

学科分类号：

100706 [药理学];

摘要：

低分子肝素(low molecular weight heparins,LMWH)是由未分级肝素(unfraction heparin-UFH,简称肝素)经化学或酶学方法解聚而成,新近研究表明,LMWH除了具有抗凝、抗血栓作用外,还有抗炎、抗补体、改善毛细血管血流紊乱状态,保护内皮细胞功能,重建机体免疫系统内稳状态等生物作用。我们就LMWH抗炎/抗细胞粘附作用机制的研究进展作一综述。

引用

页码：133 / 136

页数：4

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