Toll样受体与代谢及代谢相关疾病

被引：18

作者：

卓鉥

乐颖影

机构：

[1] 中国科学院上海生命科学研究院营养科学研究所

来源：

生命科学 | 2013年 / 25卷 / 02期

关键词：

Toll样受体; 肥胖; 胰岛素抵抗; 糖尿病; 脂肪肝; 动脉粥样硬化; 生理性代谢调控;

D O I：

10.13376/j.cbls/2013.02.003

中图分类号：

R58 [内分泌腺疾病及代谢病];

学科分类号：

100201 [内科学];

摘要：

Toll样受体(Toll-like receptors,TLRs)属于模式识别受体家族,通过识别病原相关分子模式,在天然免疫反应中发挥重要作用。TLRs还是连接天然免疫反应和适应性免疫反应的桥梁。近年来的研究发现,TLRs介导的炎症反应参与代谢相关疾病的发生发展。将对TLRs在肥胖、胰岛素抵抗、糖尿病、脂肪肝和动脉粥样硬化发生发展中的作用,以及TLRs在生理性代谢调控中的作用的最新进展作一综述。Toll样受体作为连接炎症和代谢调控的关键分子,是预防和治疗代谢相关疾病的潜在靶标。

引用

页码：158 / 168

页数：11

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