柚皮素对铅致大鼠血液和脑损伤的保护作用

被引：6

作者：

朱华丽

汪纪仓

张才

王宏伟

杨自军

机构：

[1] 河南科技大学动物科技学院

来源：

中国兽医学报 | 2014年 / 34卷 / 03期

关键词：

铅; 柚皮素; 血液; 脑;

D O I：

暂无

中图分类号：

S856.9 [其他]; X503.22 [动物];

学科分类号：

090604 [动物药学]; 100402 [劳动卫生与环境卫生学];

摘要：

铅是一种重要的环境污染物,为探讨柚皮素对铅致大鼠血液和脑损伤的保护作用。24只健康雄性SD大鼠随机分为对照组、铅组、柚皮素组、铅+柚皮素组。各组每日分别灌服生理盐水、醋酸铅、柚皮素、醋酸铅和柚皮素。连续8周后,处死大鼠收集血液和脑组织。检测大鼠血液中红细胞(RBC)数和血红蛋白(Hb)含量,脑组织中丙二醛(MDA)、还原型谷胱甘肽(GSH)、超氧化物歧化酶(SOD)和过氧化氢酶(CAT)含量。结果表明,铅可显著降低RBC数和Hb含量(P<0.05),极显著提高MDA含量(P<0.01),极显著或显著降低GSH含量(P<0.01)和SOD、CAT活性(P<0.05)。柚皮素对上述生化指标无影响,但能升高铅处理大鼠血液中RBC数和Hb含量,降低脑组织中MDA含量(P<0.05),显著提高GSH含量和SOD、CAT活性(P<0.05)。说明铅可导致大鼠血液和脑损伤,柚皮素对铅导致的损伤具有一定保护作用。

引用

页码：496 / 499

页数：4

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