Effect of Tianhuang Granule(田黄冲剂) on Intracranial Pressure and Serum Matrix Metalloproteinase-9 in Patients with Acute Cerebral Hemorrhage

<正>Objective:To study the effect and mechanism of Tianhuang Granule(田黄冲剂,THG)on hydrocephalus in the patients with acute cerebral hemorrhage(ACH)through intracranial pressure(ICP) monitoring,serum matrix metalloproteinase-9(MMP-9)level observation,and National Institutes of Health Stroke Scale(NIHSS)scoring(for nerve function deficit).Methods:Sixty patients with ACH were equally randomized into two groups by lottery,the control group and the THG group;all were treated with conventional therapy, but to the patients in the THG group,THG was given orally in addition for 28 days.Changes of ICP,MMP-9 expression,and NIHSS scores,as well as the degree of cerebral hematoma and hydrocephalus(by cranial CT scanning)in the patients,were estimated and compared.Results:(1)ICP was lowered more significantly in the THG group,showing a significant difference between groups on day 7(P<0.05).(2)MMP-9 expression was down-regulated in the THG group more significantly and earlier than that in the control group.(3)The degrees of cerebral hematoma and hydrocephalus in the THG group on day 7 were reduced significantly as compared with those on day 3(P<0.05),but in the control group,the day of significant reduction was delayed to day 14,and the degrees on day 7 and day 14 in the two groups were significantly different(P<0.05 and P<0.01).(4)NIHSS score was significantly lower in the THG group than that in the control group on day 14 and day 28(P<0.05 and P<0.01).Conclusion:THG can effectively lower ICP,down-regulate MMP-9 expression,promote the absorption of cerebral hematoma and hydrocephalus,and improve the nerve function,showing a clinical effectiveness than conventional therapy.