黄酮和黄酮醇通过诱导PIG3表达引发人食管癌细胞凋亡

被引：12

作者：

张强

赵新淮

机构：

[1] 东北农业大学,乳品科学教育部重点实验室

来源：

生物化学与生物物理进展 | 2009年 / 36卷 / 02期

关键词：

黄酮; 黄酮醇; 分子机制; 细胞凋亡; 癌症;

D O I：

暂无

中图分类号：

R735.1 [食管肿瘤];

学科分类号：

100214 ;

摘要：

采用两株人食管癌细胞(鳞癌KYSE-510和腺癌OE33)为肿瘤模型,在体外探讨黄酮、黄酮醇化合物诱导细胞凋亡的分子机制.DNA片段化、吖啶橙染色以及流式细胞术的分析结果表明,3种黄酮(木犀草素、白杨素、芹菜素)和3种黄酮醇(槲皮素、山奈酚、杨梅素)均能诱导两株食管癌细胞发生凋亡.荧光定量RT-PCR和Western-blot分析结果表明,黄酮和黄酮醇是通过诱导PIG3 mRNA和蛋白质的表达、经线粒体途径以非p53依赖的方式,引发两株食管癌细胞凋亡.同时,这一过程可能受到p63和p73的调节.

引用

页码：213 / 219

页数：7

共 9 条

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