邻苯二甲酸酐哮喘实验动物模型制备及病理学观察

被引:4
作者
张星东
刘镜愉
机构
[1] 北京医科大学第三医院职业病研究中心,北京医科大学第三医院职业病研究中心北京,北京
关键词
职业性哮喘; 邻苯二甲酸酐; 动物模型; 病理;
D O I
暂无
中图分类号
学科分类号
摘要
45只体重250—300克的豚鼠用邻苯二甲酸酐—牛血清白蛋白注射免疫,15只正常豚鼠作对照。吸入邻苯二甲酸酐—人血清白蛋白后,实验组有40只动物(88%)出现哮喘发作。用其中4只哮喘动物血清给正常未致敏豚鼠做被动转移试验,亦同样诱发致哮喘。哮喘动物的病理学观察表现为支气管壁的嗜酸性粒细胞浸润,管腔中有由嗜酸性粒细胞、粘液及少许脱落的上皮细胞组成的栓塞,肺泡腔扩大,肺泡壁变薄等一系列符合一般变应性哮喘的形态学改变。
引用
收藏
页码:24 / 26+65-66
页数:5
相关论文
共 7 条
[1]  
Immune responses of cynomolgus monkeys to phthalic anhydride. Biagini R E,et al. The Journal of Allergy and Clinical Immunology . 1988
[2]  
Asthma and rhinitis due to senwitization to phthalic anhydride:report of a case. Kern R A. Journal of Allergy . 1939
[3]  
In vitro demonstration of specific IgE in phthalic anhydride hypersensitivity. Maccia C A,et al. The American Review of Respiratory Disease . 1976
[4]  
Clinical and immunologic evaluation of trimellitic anhydride and phthalic anhydride exposed workers using a questionnaire with comparative analysis of enzyme-linked immunosorbent and radioimmunoassay studies. Bernstein D I,et al. The Journal of Allergy and Clinical Immunology . 1982
[5]  
Heterogenicity of specific IgE responses in workers sensitized to acid anhydride compounds. Bernstein D I,dt al. The Journal of Allergy and Clinical Immunology . 1984
[6]  
Phthalic anhydride-induced occupational asthms. Margareta Wernnfos,et al. Int Allergy appl Immun . 1986
[7]  
Bronchoalveolar lavge and histologic characterization of late asthmatic response in guinea pigs. Iijima H et al. The American Review of Respiratory Disease . 1987