PI3K/Akt信号通路在肿瘤血管形成中的作用研究进展

被引：22

作者：

张洪英

陈军宝

卢宏柱

机构：

[1] 长江大学临床医学院

来源：

山东医药 | 2012年 / 47期

关键词：

PI3K/Akt; 肿瘤血管形成; 血管内皮细胞; 血管内皮生长因子; 一氧化氮;

D O I：

暂无

中图分类号：

R730.23 [肿瘤病理生理学];

学科分类号：

100214 [肿瘤学];

摘要：

<正>磷脂酰肌醇-3激酶/蛋白激酶B(PI3K/Akt)信号通路在抑制细胞凋亡、促进细胞增殖等方面具有重要作用。近年来越来越多的研究发现其与肺癌、乳腺癌、结直肠癌、前列腺癌、卵巢癌、肝癌及淋巴瘤的发生、发展密切相关。血管形成是肿瘤生长的重要环节,受血管内皮生长因子、表皮生长因子受体、血管生成素等的调控。现将近年来有关P13K/AKT信号通路在肿瘤血管形成中的作用研究进展情况综述如下。

引用

页码：98 / 100

页数：3

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