加兰他敏对阿尔茨海默病大鼠认知功能的影响

被引:3
作者
曹续政
张黎明
沈月娥
周珊珊
机构
[1] 哈尔滨医科大学第一附属医院神经内科
关键词
加兰他敏; 阿尔茨海默病; 链脲菌素;
D O I
10.13241/j.cnki.pmb.2007.08.042
中图分类号
R749.16 [];
学科分类号
100203 ;
摘要
目的:研究加兰他敏对阿尔茨海默病大鼠认知功能的影响。方法:雄性SD大鼠35只,随机分为假手术组(10只)、链脲菌素(STZ)组(10只),加兰他敏组(15只)。侧脑室注射STZ制备阿尔茨海默病大鼠模型,水迷宫试验测定大鼠的学习记忆能力。加兰他敏3mg/kg,共6周。结果:术前三个组之间潜伏期及过平台次数无明显差异,术后第10天加兰他敏组潜伏期为48.64±8.41s,过平台次数为0.74±0.40,与STZ组比较,差异无统计学意义。治疗6周后加兰他敏组潜伏期为26.33±9.51s,过平台次数为3.33±1.51,与STZ组比较,差异有显著统计学意义。结论:加兰他敏对阿尔茨海默病大鼠的认知功能具有明显的改善作用。
引用
收藏
页码:1166 / 1167
页数:2
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