新生儿HIE脑水肿的发生机制及其DWI、DTI特征与AQP-4的相关性

被引：4

作者：

王宏伟

王晓明

郭启勇

机构：

[1] 中国医科大学附属盛京医院放射科

来源：

中国医学影像技术 | 2008年 / 04期

关键词：

缺氧缺血性脑病; 水通道蛋白-4; 扩散加权成像; 扩散张量成像;

D O I：

10.13929/j.1003-3289.2008.04.019

中图分类号：

R722.1 [新生儿疾病];

学科分类号：

100202 ;

摘要：

脑水肿是新生儿缺氧缺血性脑病的早期病理生理学改变,DWI、DTI可以准确监测脑水肿的影像信号变化过程。近来研究表明AQP-4与脑水肿关系密切,并与新生儿HIE脑水肿的DWI、DTI表现相关联。现对AQP-4与新生儿HIE脑水肿的发生机制及其DWI、DTI特征的相关性进行综述。

引用

页码：622 / 625

页数：4

共 10 条

[1] Aquaporin-4 and brain edema [J].

Papadopoulos, Marios C. ;

Verkman, Alan S. .

PEDIATRIC NEPHROLOGY, 2007, 22 (06) :778-784

[2] Noninvasive early detection of brain edema in mice by near-infrared light scattering [J].

Thiagarajah, JR ;

Papadopoulos, MC ;

Verkman, AS .

JOURNAL OF NEUROSCIENCE RESEARCH, 2005, 80 (02) :293-299

[3] Effect of mild hypothermia on the expression of aquaporin family in cultured rat astrocytes under hypoxic condition [J].

Fujita, Y ;

Yamamoto, N ;

Sobue, K ;

Inagaki, M ;

Ito, H ;

Arima, H ;

Morishima, T ;

Takeuchi, A ;

Tsuda, T ;

Katsuya, H ;

Asai, K .

NEUROSCIENCE RESEARCH, 2003, 47 (04) :437-444

[4] Enhanced expression of aquaporin 4 in human brain with infarction [J].

Aoki, K ;

Uchihara, T ;

Tsuchiya, K ;

Nakamura, A ;

Ikeda, K ;

Wakayama, Y .

ACTA NEUROPATHOLOGICA, 2003, 106 (02) :121-124

[5]

Differential regulation of aquaporin expression in astrocytes by protein kinase C[J] . Naoki Yamamoto,Kazuya Sobue,Taishi Miyachi,Masaaki Inagaki,Yutaka Miura,Hirotada Katsuya,Kiyofumi Asai.Molecular Brain Research . 2001 (1)

[6]

Regulation of aquaporin-4 expression in astrocytes[J] . Kazuhiro Yoneda,Naoki Yamamoto,Kiyofumi Asai,Kazuya Sobue,Yoshihito Fujita,Masataka Fujita,Mitsuhito Mase,Kazuo Yamada,Makoto Nakanishi,Toyohiro Tada,Yutaka Miura,Taiji Kato.Molecular Brain Research . 2001 (1)

[7] Alterations in the expression of the AQP family in cultured rat astrocytes during hypoxia and reoxygenation [J].

Yamamoto, N ;

Yoneda, K ;

Asai, K ;

Sobue, K ;

Tada, T ;

Fujita, Y ;

Katsuya, H ;

Fujita, M ;

Aihara, N ;

Mase, M ;

Yamada, K ;

Miura, Y ;

Kato, T .

MOLECULAR BRAIN RESEARCH, 2001, 90 (01) :26-38

[8]

Differential Upregulation of Aquaporin-4 mRNA Expression in Reactive Astrocytes after Brain Injury: Potential Role in Brain Edema[J] . Neurobiology of Disease . 1999 (4)

[9]

Time course of aquaporin expression after transient focal cerebral ischemia in mice. Ribeiro Mde C,Hirt L,Bogousslavsky J,Regli L, et al. Journal of Neuroscience Research . 2006

[10]

Transient hypoxia-ischemia in rats: changes in diffusion-sensitive MR imaging findings, extracellular space, and Na+-K+-adenosine triphosphatase and cytochrome oxidase activity. Qiao M, Malisza KL, Del Bigio MR, et al. Radiology . 2002

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