泛素C末端水解酶-1在急性缺血性脑血管病早期鉴别中的应用价值

被引：5

作者：

张炜

苏萍

邝兆威

机构：

[1] 东莞市塘厦医院

来源：

山东医药 | 2013年 / 53卷 / 24期

关键词：

超急性脑梗死; 腔隙性脑梗死; 短暂性脑缺血发作; 泛素C末端水解酶-1; 早期诊断;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

目的评价血清泛素C末端水解酶-1(UCH-L1)在急性缺血性脑血管病早期鉴别中的应用价值。方法采用前瞻性设计,连续观察发病6 h内表现为急性局灶性神经功能缺损的患者102例,分为超急性脑梗死(HCI)组[除外腔隙性脑梗死(LACI)]40例、LACI组32例、短暂性脑缺血发作(TIA)组30例。用夹心ELISA法测定三组发病6 h内血清UCH-L1,采用受试者工作特征(ROC)曲线分析血清UCH-L1对HCI的诊断价值。结果 HCI、LA-CI、TIA组血清UCH-L1水平分别为0.24(0.21)、0.13(0.09)、0.13(0.07)μg/L,HCI组血清UCH-L1水平显著高于LACI、TIA组(P均<0.001),LACI组血清UCH-L1水平与TIA组无显著性差异(P>0.05)。血清UCH-L1诊断HCI(除外LACI)的ROC曲线下面积为0.793±0.047(P<0.01,95%CI 0.700～0.886),最佳截断点血清UCH-L1水平为0.17μg/L。当血清UCH-L1≥0.17μg/L时,其诊断HCI的灵敏度为72.5%、特异度为74.2%、阳性预测值为64.4%、阴性预测值为80.7%。结论血清UCH-L1水平检测有助于HCI与TIA、LACI的早期鉴别。

引用

页码：15 / 17

页数：3

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