睡眠障碍对免疫系统及疾病影响的研究进展

被引：24

作者：

杨冀

于卉影

机构：

[1] 沈阳军区总医院医学实验科

来源：

转化医学电子杂志 | 2017年 / 4卷 / 10期

关键词：

睡眠; 睡眠障碍; 免疫系统; 疾病;

D O I：

暂无

中图分类号：

R740 [];

学科分类号：

摘要：

由于受到睡眠问题困扰的人群逐年增加,因此睡眠与健康问题受到了越来越多的关注.睡眠在免疫系统调控中发挥着重要的作用.夜间睡眠期间,一些免疫细胞(如适应性免疫细胞)的数量和促炎性细胞因子水平达到峰值,而具有直接效应功能的细胞(如NK细胞)和抗炎性细胞因子水平在日间觉醒时达到峰值.而睡眠破坏后,免疫细胞数量和活性降低以及炎症激活,引起免疫防御功能下降,从而导致感染性疾病患病风险增加、疫苗保护作用降低,以及心血管疾病、代谢性疾病和癌症的发病率增加.本文就睡眠障碍对免疫功能和疾病影响的研究进展作一综述,提出通过改善睡眠,恢复机体免疫功能,进而预防和控制相关疾病的发生.

引用

页码：66 / 70

页数：5

共 29 条

[1]

Is Insomnia a Risk Factor for Decreased Influenza Vaccine Response? [J].

Taylor, Daniel J. ;

Kelly, Kimberly ;

Kohut, Marian L. ;

Song, Kai-Sheng .

BEHAVIORAL SLEEP MEDICINE, 2017, 15 (04) :270-287

[2]

Immunity around the clock [J].

Man, Kevin ;

Loudon, Andrew ;

Chawla, Ajay .

SCIENCE, 2016, 354 (6315) :999-1003

[3]

Effects of Sleep Deprivation on Mice Bone Marrow and Spleen B Lymphopoiesis [J].

Lungato, Lisandro ;

Nogueira-Pedro, Amanda ;

Dias, Carolina Carvalho ;

Paredes-Gamero, Edgar Julian ;

Tufik, Sergio ;

D'Almeida, Vania .

JOURNAL OF CELLULAR PHYSIOLOGY, 2016, 231 (06) :1313-1320

[4]

Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation [J].

Irwin, Michael R. ;

Olmstead, Richard ;

Carroll, Judith E. .

BIOLOGICAL PSYCHIATRY, 2016, 80 (01) :40-52

[5]

Sleep-deprivation reduces NK cell number and function mediated by β-adrenergic signalling.[J].Beatriz H.P. De Lorenzo;Laís de Oliveira Marchioro;Carollina Ribeiro Greco;Deborah Suchecki.Psychoneuroendocrinology.2015,

[6]

Sleep disruption and its effect on lymphocyte redeployment following an acute bout of exercise.[J].Lesley A. Ingram;Richard J. Simpson;Eva Malone;Geraint D. Florida-James.Brain Behavior and Immunity.2015,

[7]

Disruption of Circadian Rhythms and Sleep in Critical Illness and its Impact on Innate Immunity [J].

Dengler, Viola ;

Westphalen, Kristin ;

Koeppen, Michael .

CURRENT PHARMACEUTICAL DESIGN, 2015, 21 (24) :3469-3476

[8]

Why Sleep Is Important for Health: A Psychoneuroimmunology Perspective.[J].Michael R. Irwin.Annual Review of Psychology.2015, 1

[9]

Acute sleep deprivation in healthy young men: Impact on population diversity and function of circulating neutrophils.[J].Gustaf Christoffersson;Evelina Vågesjö;Ulrika S. Pettersson;Sara Massena;Emil K. Nilsson;Jan-Erik Broman;Helgi B. Schiöth;Christian Benedict;Mia Phillipson.Brain Behavior and Immunity.2014,

[10]

Self-reported sleep duration, white blood cell counts and cytokine profiles in European adolescents: the HELENA study [J].

Perez de Heredia, Fatima ;

Garaulet, Marta ;

Gomez-Martnez, Sonia ;

Diaz, Ligia E. ;

Warnberg, Julia ;

Androutsos, Odysseas ;

Michels, Nathalie ;

Breidenassel, Christina ;

Cuenca-Garcia, Magdalena ;

Huybrechts, Inge ;

Gottrand, Frederic ;

Ferrari, Marika ;

Santaliestra-Pasias, Alba M. ;

Kafatos, Anthony ;

Molnar, Denes ;

Sjostrom, Michael ;

Widhalm, Kurt ;

Moreno, Luis A. ;

Marcos, Ascension .

SLEEP MEDICINE, 2014, 15 (10) :1251-1258

← 1 2 3 →