加兰他敏治疗阿尔茨海默病的作用机制

被引：12

作者：

张艳

李倩倩

赵兴鹃

机构：

[1] 哈尔滨医科大学附属第一医院神经内科

来源：

中国神经免疫学和神经病学杂志 | 2011年 / 18卷 / 03期

关键词：

加兰他敏; 阿尔茨海默病; 烟碱型乙酰胆碱受体;

D O I：

暂无

中图分类号：

R749.16 [];

学科分类号：

100203 ;

摘要：

加兰他敏是一种从石蒜科植物中提取的菲啶类生物碱,具有多重作用机制:作为一种可逆性的胆碱酯酶抑制剂,能增加神经肌肉突触间隙内乙酰胆碱的浓度;作为变构增强配体可使烟碱型乙酰胆碱受体(nico-tinic acetylcholine receptor,nAChR)活化,具有神经保护功能;可作用于淀粉样前体蛋白的代谢途径,减少β淀粉样蛋白(Aβ)的生成;同时,加兰他敏还具有疾病调节作用,能抑制Aβ的聚集和/或毒性。现就加兰他敏在治疗阿尔茨海默病中的作用机制进行综述。

引用

页码：220 / 223

页数：4

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