高血压血管重构的力学调控机制研究进展

被引：30

作者：

陈志彦

徐明

高炜

机构：

[1] 北京大学第三医院心内科心血管分子生物学与调节肽卫计委重点实验室分子心血管学教育部重点实验室

来源：

生理科学进展 | 2017年 / 48卷 / 01期

基金：

北京市自然科学基金;

关键词：

高血压; 血管重构; 剪切力; 环形张力;

D O I：

暂无

中图分类号：

R544.1 [高血压];

学科分类号：

100201 [内科学];

摘要：

血流动力学紊乱是高血压病理过程中促进血管重构发生发展的重要原因。由其引起的异常剪切力和环形张力可以被细胞表面的力学感受器识别,并转化为细胞内生物学信号,引起血管结构和功能上的改变,介导血管的重构,增加心血管疾病的发生风险。因此,明确血管重构过程中的力学调控机制,对预防和改善高血压所致的心血管疾病具有重要意义。本文就高血压病理生理过程中血管重构的力学调控机制进展予以简要阐述。

引用

页码：77 / 81

页数：5

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