IL-1、TNF在局部脑缺血/再灌注中的表达

被引：10

作者：

李岚

屠永华

赵光东

机构：

[1] 解放军医学高等专科学校内科教研室!大连

[2] 不详

[3] 重庆第三军医大学附属一院

来源：

中国神经免疫学和神经病学杂志 | 1999年 / 01期

关键词：

脑缺血／再灌流; 白细胞介素1; 肿瘤坏死因子;

D O I：

暂无

中图分类号：

R741.02 [神经病理学、病因学];

学科分类号：

0710 ; 071006 ;

摘要：

研究脑缺血／再灌流损伤中IL－1、TNF的来源、变化规律和作用。方法用免疫组化方法检测了局部脑缺血／再灌流大鼠模型中IL－1β、TNF－α的表达。结果缺血组（I）3hlL－1β表达增多并持续至120h，缺血再灌流组（IR）0．5hIL－1β即明显增高，高峰在24h，120h已降至对照组（C）水平，阳性细胞主要为纹状体区及顶叶皮层的神经元、胶质细胞和血管内皮细胞；I组和IR组0．5hTNF－α表达增多，12h达高峰，持续至120h，阳性细胞为纹状体和缺血皮层的神经元和胶质细胞。结论IL－1β、TNF－α参与缺血／再灌流脑损伤，其来源于损伤局部的神经元、胶质细胞及血管内皮细胞，并对其作用进行了探讨。

引用

页码：16 / 19

页数：4

共 11 条

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