血管内皮细胞损伤与高血压

被引：99

作者：

罗晓佳

陈晓平

机构：

[1] 四川大学华西医院心血管内科

来源：

心血管病学进展 | 2010年 / 31卷 / 04期

关键词：

内皮细胞损伤; 高血压; 发病机制; 心血管疾病;

D O I：

暂无

中图分类号：

R544.1 [高血压];

学科分类号：

100201 [内科学];

摘要：

近年来很多研究表明内皮细胞损伤导致的功能障碍与多种心血管疾病的发生发展有着密切相关,包括高血压、冠状动脉性心脏病、糖尿病等。深入探讨血管内皮细胞损伤的机制、评估,保护和修复内皮细胞功能,对改善心血管疾病的预后有积极的意义。现就血管内皮细胞损伤引起的内皮功能障碍和高血压发病机制之间的关系进行综述。

引用

页码：573 / 577

页数：5

共 15 条

[1]

Isolated systolic hypertension is characterized by increased aortic stiffness and endothelial dysfunction [J].

Wallace, Sharon M. L. ;

Yasmin ;

McEniery, Carmel M. ;

Maki-Petaja, Kaisa M. ;

Booth, Anthony D. ;

Cockcroft, John R. ;

Wilkinson, Ian B. .

HYPERTENSION, 2007, 50 (01) :228-233

[2]

Expression of adrenomedullin2/intermedin in human brain, heart, and kidney [J].

Morimoto, Ryo ;

Satoh, Fumitoshi ;

Murakami, Osamu ;

Totsune, Kazuhito ;

Suzuki, Takashi ;

Sasano, Hironobu ;

Ito, Sadayoshi ;

Takahashi, Kazuhiro .

PEPTIDES, 2007, 28 (05) :1095-1103

[3]

Circulating endothelial cells, endothelial progenitor cells, and endothelial microparticles in cancer [J].

Goon, P. K. Y. ;

Lip, G. Y. H. ;

Boos, C. J. ;

Stonelake, P. S. ;

Blann, A. D. .

NEOPLASIA, 2006, 8 (02) :79-88

[4]

Cardiovascular effects of newly discovered peptide intermedin/adrenomedullin 2 [J].

Pan, CS ;

Yang, JH ;

Cai, DY ;

Zhao, J ;

Gerns, H ;

Yang, J ;

Chang, JK ;

Tang, CS ;

Qi, YF .

PEPTIDES, 2005, 26 (09) :1640-1646

[5]

Long-term impact of systolic blood pressure and glycemia on the development of microalbuminuria in essential hypertension [J].

Pascual, JM ;

Rodilla, E ;

Gonzalez, C ;

Pérez-Hoyos, S ;

Redon, J .

HYPERTENSION, 2005, 45 (06) :1125-1130

[6]

Endothelin receptor antagonists - Clinical realities and future directions [J].

Kirchengast, M ;

Luz, M .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2005, 45 (02) :182-191

[7]

Endothelial dysfunction and mild renal insufficiency in essential hypertension [J].

Perticone, F ;

Maio, R ;

Tripepi, G ;

Zoccali, C .

CIRCULATION, 2004, 110 (07) :821-825

[8]

Epicardial coronary artery constriction to cold pressor test is predictive of cardiovascular events in hypertensive patients with angiographically normal coronary arteries and without other major coronary risk factor [J].

Nitenberg, A ;

Chemla, D ;

Antony, I .

ATHEROSCLEROSIS, 2004, 173 (01) :115-123

[9]

Renal effects of a new member of adrenomedullin family, adrenomedullin2, in rats [J].

Fujisawa, Y ;

Nagai, Y ;

Miyatake, A ;

Takei, Y ;

Miura, K ;

Shoukouji, T ;

Nishiyama, A ;

Kimura, S ;

Abe, Y .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2004, 497 (01) :75-80

[10]

Relationship of homocysteine to markers of platelet and endothelial activation in ‘high risk’ hypertensives: a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial.[J].Charles G.C. Spencer;Steven C. Martin;Dirk C. Felmeden;Andrew D. Blann;Gareth D. Beevers;Gregory Y.H. Lip.International Journal of Cardiology.2004, 2

← 1 2 →