子宫内膜异位症在位、异位内膜淋巴细胞亚群分布的研究

被引：7

作者：

王悦

张丽珠

王秀云

机构：

[1] 北京大学第三医院妇产科

来源：

中华妇产科杂志 | 2001年 / 02期

关键词：

子宫内膜异位症; 淋巴细胞亚群; 巨噬细胞;

D O I：

暂无

中图分类号：

R711.7 [女性生殖器其他疾病];

学科分类号：

100211 ;

摘要：

目的　探讨子宫内膜异位症 (内异症 )在位和异位内膜淋巴细胞的分布及意义。方法　采用免疫组织化学碱性磷酸酶抗碱性磷酸酶法 ,对 43例内异症患者和 19例子宫肌瘤等非内异症患者 (对照组 )的在位内膜和异位内膜中淋巴细胞及巨噬细胞亚群的数量、比例进行测定。结果　内异症患者的增殖期异位内膜局部CD+3 、CD+8、CD+68T淋巴细胞含量分别为 (6 7 2± 13 5 )个 /5HP( x±s,下同)、(4 5 0± 14 6 )个 /5HP、(37 2± 10 6 )个 /5HP ,明显多于在位内膜的 (5 2 4± 11 3)个 /5HP(P<0 0 1)、(32 5± 10 0 )个 /5HP(P <0 0 5 )、(30 7± 10 3)个 /5HP ,以及对照组内膜的 (5 2 1± 14 9)个 /5HP(P <0 0 5 )、(2 8 9± 12 7)个 /5HP(P <0 0 1)、(2 6 3± 9 3)个 /5HP(P <0 0 5 ) ;分泌期CD+8T淋巴细胞 /CD+4 T淋巴细胞比值、CD+68T淋巴细胞含量分别为 3 5± 1 2、(4 0 3± 12 2 )个 /5HP ,高于对照组内膜的 3 2± 0 8(P <0 0 5 )、(2 8 6± 10 6 )个 /5HP(P <0 0 1) ;巨噬细胞含量也明显增高。异位内膜中淋巴细胞无明显周期性改变。结论　内异症病变局部淋巴细胞和巨噬细胞的大量侵润 ,与内异症的病理形成有关。在较晚期的内异症 ,淋巴细胞和巨噬细胞不能清除异位内膜 ,反之 ,可刺激其生长

引用

页码：20 / 23+65

页数：5

共 18 条

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