简易智能精神状态量表和蒙特利尔认知评估量表差值在老年期痴呆鉴别诊断中的价值

被引：33

作者：

张筱 ^{[1
]}

袁欣瑞 ^{[1
]}

朱瑞 ^{[1
]}

崔艺耀 ^{[1
]}

彭丹涛 ^{[2
]}

机构：

[1] 北京医院神经内科

[2] 中日友好医院神经内科

来源：

中华老年医学杂志 | 2015年 / 34卷 / 05期

关键词：

痴呆; 精神病状态评估量表; 认知;

D O I：

暂无

中图分类号：

R749.1 [脑器质性精神障碍];

学科分类号：

100205 ;

摘要：

目的探讨简易智能精神状态量表(MMSE)和蒙特利尔认知评估量表(MoCA)差值在老年期痴呆鉴别诊断中的价值。方法收集就诊于我院门诊老年期痴呆患者331例, 其中阿尔茨海默病(AD)组148例, 血管性痴呆(VaD)组87例, 混合性痴呆(MD)组44例, 额颞叶痴呆(FTD)组41例, 路易体痴呆(DLB)组11例, 应用MMSE和MoCA分别评定痴呆患者的认知功能。结果 AD组MMSE与MoCA差值为(3.3±1.7)分, VaD组差值为(6.6±2.1)分, MD组差值为(6.6±2.1)分, FTD组差值为(5.4±2.3)分, DLB组差值为(6.1±1.9)分。5组间差异有统计学意义(F=46.420, P=0.000), AD组与非AD组比较差异有统计学意义(t=–13.429, P=0.000)。轻、中度痴呆中, AD组和非AD组比较, MMSE和MoCA差值均有统计学意义(P=0.000)。根据ROC曲线, 确定MMSE与MoCA差值=5分为鉴别AD和非AD痴呆的切点, 对应的敏感度和特异度分别为79.8%和78.4%, ROC曲线下面积为0.848, 95%CI为0.807～0.890。结论 MMSE与MoCA差值可作为鉴别AD和非AD痴呆的辅助诊断方法之一。

引用

页码：494 / 497

页数：4

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