姜黄素对阿霉素诱导的大鼠心脏重构及心功能改变的研究(英文)

被引：9

作者：

卢均坤 ^{[1
]}

刘洋 ^{[2
]}

吕维娟 ^{[1
]}

赵伟 ^{[3
]}

王燕琴 ^{[1
]}

机构：

[1] 佳木斯大学附属第一医院循环二科

[2] 大庆市第二医院

[3] 佳木斯大学公共卫生学院

来源：

心血管康复医学杂志 | 2013年 / 22卷 / 04期

关键词：

I型; 胶原III型; 心室功能;

D O I：

暂无

中图分类号：

R259 [现代医学内科疾病];

学科分类号：

100201 [内科学];

摘要：

目的:研究姜黄素对阿霉素引起的大鼠心脏重构及心功能改变的作用。方法:50只SD大鼠随机分为空白对照组,阿霉素组,姜黄素干预组,观察大鼠的一般情况(体重、毛色、饮食、活动能力),以超声心动图观察大鼠左室射血分数(LVEF)、左室短轴缩短分数(LVFS)、左室舒张末期内径(LVEDd),称量大鼠心脏重量,以免疫组化法观察大鼠心肌Ⅰ、Ⅲ型胶原的变化。结果:实验后,与空白对照组相比,阿霉素组大鼠心脏重量[(168.53±26)mg比(208.34±31)mg]、心脏重量/体重[(0.36±0.06)比(0.52±0.08)]显著增加,体重[(469.27±34)g比(428.47±45)g]显著减轻;LVEDd[(4.87±0.19)mm比(7.49±0.83)mm]明显增加,LVEF[(69.53±6.25)%比(41.46±4.38)%]、LVFS[(45.83±3.79)%比(17.25±2.92)%]明显降低(P均<0.05);Ⅰ、Ⅲ型胶原蛋白表达率明显升高(P<0.01)。与阿霉素组大鼠比较,姜黄素组大鼠体重(452.46±38)g显著增加,心脏重量(178.73±38)mg、心脏重量/体重(0.39±0.07)显著减轻,LVEDd(5.96±0.65)mm显著降低,LVEF(53.12±5.43)%LVFS(36.57±3.66)%显著增加(P均<0.05);Ⅰ、Ⅲ型胶原蛋白表达率明显降低()。结论:姜黄素能改善阿霉素引起的鼠心脏重构和心功能改变。

引用

页码：316 / 320

页数：5

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