慢性应激与肿瘤关系的研究进展

被引:9
作者
沈晶尧
袁爱华
马永
曹红勇
机构
[1] 南京医科大学附属南京第一医院普通外科
关键词
慢性应激; 神经内分泌介质; 昼夜节律; 心理疗法; 肿瘤;
D O I
暂无
中图分类号
R730.2 [肿瘤病理学、病因学];
学科分类号
100214 [肿瘤学];
摘要
慢性应激是个体面对特殊环境变化而不能调整和稳定内环境稳态时所经历的持续的情感及心理反应。近年来的研究表明,应激通过神经系统启动瀑布式级联效应,神经内分泌介质修饰肿瘤微环境和应激相关神经内分泌介质激活瘤细胞内增殖和转移相关信号通路,从而影响肿瘤的发生、发展和预后。理解慢性应激在肿瘤演进中的作用和机制,有利于设计合理的干预措施治疗肿瘤。
引用
收藏
页码:2624 / 2626
页数:3
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共 11 条
[1]
Effects of social isolation stress on immune response and survival time of mouse with liver cancer[J] Hui Liu; Zhun Wang; Department of Clinical Immunology; Dalian Medical University; Dalian 116027; Liaoning Province; China World Journal of Gastroenterology 2005,
[2]
Psychological distress and cancer mortality[J] Mark Hamer;Yoichi Chida;Gerard J. Molloy Journal of Psychosomatic Research 2009,
[3]
Riding Tandem: Circadian Clocks and the Cell Cycle[J] Tim Hunt;Paolo Sassone-Corsi Cell 2007,
[4]
Glucocorticoid use in prostate cancer and other solid tumours: implications for effectiveness of cytotoxic treatment and metastases[J] Ingrid Herr;Jesco Pfitzenmaier Lancet Oncology 2006,
[5]
Disruption of Circadian Coordination and Malignant Growth[J] Elizabeth Filipski;Xiaoi Mei Li;Francis Lévi Cancer Causes & Control 2006,
[6]
Stress; depression; the immune system; and cancer[J] Edna Maria Vissoci Reiche;Sandra Odebrecht Vargas Nunes;Helena Kaminami Morimoto Lancet Oncology 2004,
[7]
Psychological factors and cancer development: Evidence after 30 years of research[J] Bert Garssen Clinical Psychology Review 2004,
[8]
Increased surgical stress promotes tumor metastasis[J] Yasunori Tsuchiya;Shigeaki Sawada;Isaku Yoshioka;Yasukata Ohashi;Mitsuhiro Matsuo;Yuko Harimaya;Kazuhiro Tsukada;Ikuo Saiki Surgery 2003,
[9]
Mood disorders and allostatic load[J] Bruce S McEwen Biological Psychiatry 2003,
[10]
Circadian disruption in cancer: a neuroendocrine-immune pathway from stress to disease?[J] Sandra Sephton;David Spiegel Brain Behavior and Immunity 2003,