人乳头状瘤病毒复制机制的研究进展

被引：3

作者：

吕涛

马正海

机构：

[1] 新疆大学生命科学与技术学院新疆生物资源基因工程重点实验室

来源：

生命科学 | 2010年 / 22卷 / 08期

关键词：

人乳头状瘤病毒; 复制; E1; E2; 复制起始位点;

D O I：

10.13376/j.cbls/2010.08.015

中图分类号：

R373 [人体病毒学（致病病毒）];

学科分类号：

摘要：

人乳头状瘤病毒(human papillomavirus,HPV)DNA以游离和整合两种形式存在于感染细胞中。游离形式HPVs的复制依赖于上皮细胞的分化,病毒E1、E2蛋白和复制起始位点(origin,Ori)为复制必需元件,E1和E2蛋白与Ori结合起始病毒DNA的复制。随后,病毒DNA通过E2蛋白与Brd4(bromodomain-containing protein 4)等细胞蛋白的互作而与染色体结合,并随细胞分裂平均分配到子代细胞中。在肿瘤中,高危型HPVs的基因组通常以整合形式存在,并随细胞的增殖而复制。

引用

页码：743 / 748

页数：6

共 8 条

[1] A novel interaction between the human papillomavirus type 16 E2 and E1 E4 proteins leads to stabilization of E2 [J].

Davy, Clare ;

McIntosh, Pauline ;

Jackson, Deborah J. ;

Sorathia, Rina ;

Miell, Matthew ;

Wang, Qian ;

Khan, Jameela ;

Soneji, Yasmina ;

Doorbar, John .

VIROLOGY, 2009, 394 (02) :266-275

[2] Characterization of papillomavirus E1 helicase mutants defective for interaction with the SUMO-conjugating enzyme Ubc9 [J].

Fradet-Turcotte, Amelie ;

Brault, Karine ;

Titolo, Steve ;

Howley, Peter M. ;

Archambault, Jacques .

VIROLOGY, 2009, 395 (02) :190-201

[3] Interactions of the cellular CCAAT displacement protein and human papillomavirus E2 protein with the viral origin of replication can regulate DNA replication [J].

Narahari, Janaki ;

Fisk, John C. ;

Melendy, Thomas ;

Roman, Ann .

VIROLOGY, 2006, 350 (02) :302-311

[4] Identification of a 450-bp region of human papillomavirus type 1 that promotes episomal replication in Saccharomyces cerevisiae [J].

Chattopadhyay, A ;

Schmidt, MC ;

Khan, SA .

VIROLOGY, 2005, 340 (01) :133-142

[5] Identification of domains of the HPV11 E1 protein required for DNA replication in vitro [J].

Amin, AA ;

Titolo, S ;

Pelletier, A ;

Fink, D ;

Cordingley, MG ;

Archambault, J .

VIROLOGY, 2000, 272 (01) :137-150

[6] The E1 helicase of human papillomavirus type 11 binds to the origin of replication with low sequence specificity [J].

Dixon, EP ;

Pahel, GL ;

Rocque, WJ ;

Barnes, JA ;

Lobe, DC ;

Hanlon, MH ;

Alexander, KA ;

Chao, SF ;

Lindley, K ;

Phelps, WC .

VIROLOGY, 2000, 270 (02) :345-357

[7] Establishment of the human papillomavirus type 16 (HPV-16) life cycle in an immortalized human foreskin keratinocyte cell line [J].

Flores, ER ;

Allen-Hoffmann, BL ;

Lee, D ;

Sattler, CA ;

Lambert, PF .

VIROLOGY, 1999, 262 (02) :344-354

[8]

HPV16L1capsidprotein expressed from viable adenovirus recombinants elicits neutralizing antibody inmice .2 Berg M,Gambhira R,Siracusa M,Hoiczyk E,Roden R,Ketner G. Vaccine . 2007

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