2000～2002年北京、上海及广州三地儿童携带流感嗜血杆菌抗生素敏感性监测

被引：26

作者：

沈叙庄

陆权

邓力

俞桑洁

张泓

邓秋莲

姜敏

胡翼云

杨永弘

机构：

[1] 首都医科大学附属北京儿童医院儿科研究所微生物室,上海市儿童医院呼吸科,广州市儿童医院呼吸科,首都医科大学附属北京儿童医院儿科研究所微生物室,上海市儿童医院检验科,广州市儿童医院检验科,首都医科大学附属北京儿童医院儿科研究所微生物室,首都医科大学附属北京儿童医院儿科研究所微生物室,首都医科大学附属北京儿童医院儿科研究所微生物室,,,,

来源：

中华医学杂志 | 2004年 / 16期

关键词：

嗜血菌,流感; 抗生素类; 抗药性; β内酰胺酶类;

D O I：

暂无

中图分类号：

R446.5 [微生物学检验];

学科分类号：

100208 ;

摘要：

目的了解当前我国儿童携带流感嗜血杆菌对常用抗生素的敏感性情况,以便有效指导临床合理用药和预防。方法采用E-test最小抑菌浓度(MIC)方法及KB纸片扩散法对2000-2002年北京、上海、广州3所儿童医院上呼吸道感染儿童携带流感嗜血杆菌进行10种常用抗生素敏感性检测。结果氨苄青霉素对898株流感嗜血杆菌的MIC50和MIC90分别为0.25μg/ml和4μg/ml,敏感性88.0％,10.6％菌株对氨苄青霉素耐药,所有氨苄青霉素中度敏感株和耐药株均产β-内酰胺酶,分离株产β-内酰胺酶率为12％;分离株对阿莫西林/克拉维酸、头孢曲松、头孢呋辛敏感性均为100％;头孢克罗对分离株MIC50和MIC90分别为1.5μg/ml和3μg/ml,敏感性略低(96.1％),耐药率1.8％。流感嗜血杆菌对阿奇霉素、环丙沙星敏感率分别为100％和99％,对氯霉素、四环素、磺胺甲(?)唑/甲氧苄氨嘧啶(SMZ/TMP)耐药率分别为11％、18％、54.4％。北京和上海分离株对四环素敏感性分别为57％和61％,明显低于广州分离株(81％);广州和上海分离株对SMZ/TMP敏感性分别为47％和54％,明显高于北京株(35％);2000-2002年的3年中,分离株对氨苄青霉素敏感性呈逐年下降趋势,对氨苄青霉素总体耐药率由2000年的7.7％增加至2002年的14.5％。本研究中,34.5％分离株对8种抗生素均敏感,多重耐

引用

页码：20 / 24

页数：5

共 13 条

[1]

Antimicrobial resistance trends in community-acquired respiratory tract pathogens in the Western Pacific Region and South Africa: report from the SENTRY antimicrobial surveillance program, (1998-1999) including an in vitro evaluation of BMS284756. Bell JM,Turnidge JD,Jones RN,et al. International Journal of Antimicrobial Agents . 2002

[2]

Determination of the antimicrobial susceptibilities of Canadian isolates of Haemophilus influenzae, Streptococcus pneumoniae and Moraxella catarrhalis. Blondeau JM,Suter M,Borsos S,et al. Journal of Antimicrobial Chemotherapy . 1999

[3]

Antimicrobial susceptibility of nasopharynegal isolates of Haemophilus influenzae from healthy children in day-care centers results of multicentre study in Russia. Stratchounski LS,Kretchikova OI,Reshedko GK,et al. International Journal of Antimicrobial Agents . 2001

[4]

The evolving threat of antibiotic resistance in Europe: new data from the Alexander Project. Schito GC,Debbia EA,Marchese A. Journal of Antimicrobial Chemotherapy . 2000

[5]

Pathogen of occurrence and susceptibility patterns associated with pneumonia in hospitalized patients in North America: results of the SENTRY antimicrobial surveillance study (2000). Hoban DJ,Biedenbach DJ,Mutnick AH,et al. Diagnostic Microbiology and Infectious Disease . 2003

[6]

Worldwide prevalence of antimicrobial resistance in Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in the SENTRY antimicrobial surveillance program, 1997-1999. Hoban DJ,Doern GV,Fluit AC,et al. Clinical Infectious Diseases .

[7]

Resistance surveillance of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolated in Asia and Europe, 1997-1998. Sahm DF,Jones ME,Hickey ML,et al. Journal of Antimicrobial Chemotherapy . 2000

[8]

The Alexander Project 1996-1997: latest susceptibility data from this international study of bacterial pathogens from community-acquired lower respiratory tract infections. Felmingham D,Gruneberg RN,Alexander Project Group. Journal of Antimicrobial Chemotherapy . 2000

[9]

The PROTEKT surveillance study: antimicrobial susceptibility of Haemophilus influenzae and Moraxella catarrhalis from community-acquired respiratory tract infections. Hoban D,Felmingham D. Journal of Antimicrobial Chemotherapy . 2002

[10]

Antimicrobial susceptibility of Haemophilus influenzae among children in Beijing, China, 1999-2000. Hu YY,Yu SJ,Liu G,et al. Acta Paediatrica . 2002

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