细胞间粘附分子-1在哮喘患儿气道上皮细胞的表达及临床意义附视频

被引：2

作者：

赵顺英

戚豫

刘玺诚

江沁波

刘世英

姜英

江载芳

机构：

[1] 北京儿童医院

[2] 北京大学第一医院

来源：

中国实用儿科杂志 | 2002年 / 01期

关键词：

哮喘; 细胞间粘附分子-1; 上皮细胞;

D O I：

暂无

中图分类号：

R725.6 [小儿呼吸系及胸部疾病];

学科分类号：

摘要：

目的　了解细胞间粘附分子 1(intercellularadhensionmolecule 1,ICAM 1)在哮喘患儿气道炎症中的作用。方法　通过纤维支气管镜活检气道粘膜 ,分别进行病理、免疫组织化学及原位杂交检查 ,观察气道粘膜炎症和ICAM 1及其mRNA在哮喘患儿气道上皮细胞的表达 ,并与对照儿童比较。结果　哮喘患儿存在气道粘膜炎症 ,ICAM 1及其mRNA在哮喘患儿气道上皮细胞的表达增加。结论　ICAM 1在哮喘患儿气道上皮细胞的高表达与气道炎症有关

引用

页码：32 / 34

页数：3

共 8 条

[1]

The expression of Intercellular adhesion molecule-1 and β1-integrins in asthma. Manolitsas ND,Trigg CJ,McAulay AE,et al. European Respiratory Journal . 1994

[2]

A community study of the role of viral infection in exacerbation of asthma in 9-11 year old children. Johnston SL,Pattemore PK,Sanderson G. British Medical Journal . 1995

[3]

Cell adhesion molecules and asthma. Bloemen PGM,Henricks PAJ,Nilkamp FP. Clinical and Experimental Allergy . 1997

[4]

The role of ICAM-1 on T-cells in the pathogenesis of asthma. Stanciu LA,Djukanovic R. European Respiratory Journal . 1998

[5]

Cloning of the intercellular adhesion molecule 1 and analysis of its 5’regulation region. Voraberger G,Schafer R,Stratowa C. J Immunol . 1991

[6]

HLA-DR and ICAM-1 expression on bronchial epithelial cells in asthma and chronic bronchitis. Vignola AM,Campbell AM,Chanez P,et al. The American Review of Respiratory Disease . 1993

[7]

Overlaping pattens of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. Rober JS,Gimbrone LA,Lapierre DL. J Immunol . 1989

[8]

In situ expression of the cell adhesion molecules in bronchial tissues from asthma with air flow limitation. Ohkawara Y,Yamauchi K,Maruyama N,et al. Am J Respir Cell Mol Biol . 1995

← 1 →