血小板激活因子在SMAO休克发病过程中的变化及山莨菪碱的影响

被引:6
作者
陈青
苏静怡
唐朝枢
机构
[1] 北京医科大学病理生理教研室,北京医科大学病理生理教研室,北京医科大学病理生理教研室
关键词
磷脂类; 小肠; 阿托品衍生物;
D O I
暂无
中图分类号
学科分类号
摘要
本工作在家兔肠系膜上动脉闭塞性休克(SMAO休克)模型上观察血浆PAF活性变化及山莨菪碱的影响。结果发现SMAO休克动物血浆PAF水平随休克过程发展进行性增加(基础值为3.88±0.82AU/ml,开夹后2小时为9.71±1.26AU/ml,P<0.01)。血浆PAF水平与动物血压呈显著负相关关系(r=-0.97,P<0.01)。夹闭SMA前直用山茛菪碱(5mg/kg),能防止血压明显下降,降低动物死亡率,并显著抑制血浆PAF活性的增加(基础值为4.66±0.74AU/ml,开夹后2小时为7.06±0.90AU/ml,与对照组比较P<0.05)。实验结果提示山莨菪碱抑制缺血小肠产生或释放PAF可能是其抗休克效应的机制之一。
引用
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页码:650 / 652
页数:3
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