CD74 in antigen presentation,inflammation,and cancers of the gastrointestinal tract

被引：10

作者：

Ellen J Beswick ^{[1
]}

Victor E Reyes ^{[2
]}

机构：

[1] Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555, United States

[2] Department of Pediatrics and Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, United States

来源：

World Journal of Gastroenterology | 2009年 / 15卷 / 23期

基金：

美国国家卫生研究院;

关键词：

CD74; Invariant chain; Cancer; Inflammation; Helicobacter pylori; Gastrointestinal tract;

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

1002 ; 100201 ;

摘要：

CD74 is a protein whose initial role in antigen presentation was recognized two decades ago. Recent studies have revealed that it has additional functions as a receptor for macrophage migration inhibitory factor and as a receptor for an important human pathogen, Helicobacter pylori (H pylori). The role of CD74 as a receptor is important because after binding of migration inhibitory factor or H pylori, NF-κB and Erk1/2 activation occurs, along with the induction of proinflammatory cytokine secretion. This review provides an up-to-date account of the functions of CD74 and how it might be involved in inflammation and cancer within the gastrointestinal tract.

引用

页码：2855 / 2861

页数：7

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