OPG-RANKL-RANK信号通路——绝经后骨质疏松症的重要作用机制

被引：26

作者：

刘强

机构：

[1] 山西白求恩医院骨科,太原

来源：

中华骨科杂志 | 2021年 / 41卷 / 10期

关键词：

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

摘要：

骨质疏松症是一种较为多见的全身性代谢性骨病, 其主要特征为骨量低、骨组织微结构损坏, 从而导致骨脆性增加、易发生骨折。随着我国人口的老龄化, 骨质疏松症和骨质疏松性骨折越来越严重威胁着人民群众的身体健康。通过对我国骨质疏松症诊疗现状、OPG-RANKL-RANK信号通路在骨质疏松症病理生理中的作用、地舒单抗在绝经后骨质疏松症治疗中的研究进展进行研究, 为绝经后骨质疏松症的临床实践提供参考。

引用

共 24 条

[1]

原发性骨质疏松症诊疗指南(2017).[J]..中华骨质疏松和骨矿盐疾病杂志.2017, 05

[2]

The Prevalence of Osteoporosis in China, a Nationwide, Multicenter DXA Survey [J].

Zeng, Qiang ;

Li, Na ;

Wang, Qianqian ;

Feng, Jian ;

Sun, Dongmao ;

Zhang, Qiu ;

Huang, Jiyuan ;

Wen, Qingxiang ;

Hu, Rong ;

Wang, Liang ;

Ma, Yuanzheng ;

Fu, Xiaoxia ;

Dong, Shengyong ;

Cheng, Xiaoguang .

JOURNAL OF BONE AND MINERAL RESEARCH, 2019, 34 (10) :1789-1797

[3]

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism.[J]...2018,

[4]

10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension [J].

Bone, Henry G. ;

Wagman, Rachel B. ;

Brandi, Maria L. ;

Brown, Jacques P. ;

Chapurlat, Roland ;

Cummings, Steven R. ;

Czerwinski, Edward ;

Fahrleitner-Pammer, Astrid ;

Kendler, David L. ;

Lippuner, Kurt ;

Reginster, Jean-Yves ;

Roux, Christian ;

Malouf, Jorge ;

Bradley, Michelle N. ;

Daizadeh, Nadia S. ;

Wang, Andrea ;

Dakin, Paula ;

Pannacciulli, Nicola ;

Dempster, David W. ;

Papapoulos, Socrates .

LANCET DIABETES & ENDOCRINOLOGY, 2017, 5 (07) :513-523

[5]

Projection of osteoporosis-related fractures and costs in China: 2010-2050 [J].

Si, L. ;

Winzenberg, T. M. ;

Jiang, Q. ;

Chen, M. ;

Palmer, A. J. .

OSTEOPOROSIS INTERNATIONAL, 2015, 26 (07) :1929-1937

[6]

Capture the Fracture: a Best Practice Framework and global campaign to break the fragility fracture cycle [J].

Akesson, K. ;

Marsh, D. ;

Mitchell, P. J. ;

McLellan, A. R. ;

Stenmark, J. ;

Pierroz, D. D. ;

Kyer, C. ;

Cooper, C. .

OSTEOPOROSIS INTERNATIONAL, 2013, 24 (08) :2135-2152

[7]

Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumab [J].

Lacey, David L. ;

Boyle, William J. ;

Simonet, W. Scott ;

Kostenuik, Paul J. ;

Dougall, William C. ;

Sullivan, John K. ;

San Martin, Javier ;

Dansey, Roger .

NATURE REVIEWS DRUG DISCOVERY, 2012, 11 (05) :401-+

[8]

Effects of Denosumab on Bone Mineral Density and Bone Turnover in Postmenopausal Women Transitioning From Alendronate Therapy [J].

Kendler, David L. ;

Roux, Christian ;

Benhamou, Claude Laurent ;

Brown, Jacques P. ;

Lillestol, Michael ;

Siddhanti, Suresh ;

Man, Hoi-Shen ;

Martin, Javier San ;

Bone, Henry G. .

JOURNAL OF BONE AND MINERAL RESEARCH, 2010, 25 (01) :72-81

[9]

Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis [J].

Cummings, Steven R. ;

San Martin, Javier ;

McClung, Michael R. ;

Siris, Ethel S. ;

Eastell, Richard ;

Reid, Ian R. ;

Delmas, Pierre ;

Zoog, Holly B. ;

Austin, Matt ;

Wang, Andrea ;

Kutilek, Stepan ;

Adami, Silvano ;

Zanchetta, Jose ;

Libanati, Cesar ;

Siddhanti, Suresh ;

Christiansen, Claus .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (08) :756-765

[10]

Mortality Risk Associated With Low-Trauma Osteoporotic Fracture and Subsequent Fracture in Men and Women [J].

Bliuc, Dana ;

Nguyen, D. Nguyen ;

Milch, Vivienne E. ;

Nguyen, Tuan V. ;

Eisman, John A. ;

Center, Jacqueline R. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2009, 301 (05) :513-521

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