三七总皂苷的抗炎作用(英文)

被引：31

作者：

李淑慧

楚延

机构：

[1] 华西医科大学药理教研室!成都

[2] 中国

来源：

Acta Pharmacologica Sinica | 1999年 / 06期

关键词：

人参; 皂苷类; 炎症; 非甾醇抗炎剂; 磷脂酶A类; 地诺前列酮; 钙; 角叉菜胶; 中性白细胞; 地塞米松;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

1008 ;

摘要：

研究三七总皂苷（ＰｎＳ）抗炎作用．方法：用角叉菜胶复制大鼠气囊滑膜炎模型．蛋白含量、ＰＬＡＺ活性、Ｄｉｎ含量及炎细胞内游离钙水平分别用Ｌｏｗｒｙ法、微量酸滴定法、放射免疫分析法及Ｆｕｒａ２－ＡＭ荧光分析法进行测定．结果：ＰｎＳ（６０－２４０ｍｇ· ｋｇ－１）明显抑制角叉菜胶诱导的白细胞数升高和蛋白渗出；抑制灌洗液ＰＬＡ２活性，降低Ｄｉｎ含量；阻止炎细胞内游离钙水平的升高．结论：ＰｎＳ具有明显抗炎作用，其作用机制与其阻止炎细胞内游离钙水平的升高及其抑制ＰＬＡ２活性、减少Ｄｉｎ释放有密切关系．

引用

页码：551 / 554

页数：4

共 9 条

[1]

Interfacial catalysis: the mechanism ofphospholipase A2. Scott DL,White SP,Otwinowski Z,Yuan W,Gelb MH,Sigler PB. Science . 1990

[2]

Radioimmunoassay for prostaglandin E2. Cheng JX,Duan JH,Han FY,Ge L,Wang ZG,Shi YQ. Chin Acad Med Sci . 1987

[3]

Effect of aristolochic acid on arachidonic acidcascade and in vivo models of inflammation. Moreno JJ. Immunopharmacology . 1993

[4]

Protein measurement with the Folin phenol reagent. Lowry OH,Rosebrongh NJ,Farr AL,Randall RJ. Journal of Biological Chemistry . 1951

[5]

A new generationof Ca2+ indicators with greatly caved fluorescenceproperties. Grynkieicz G,Poenie M,Tsien RY. Journal of Biological Chemistry . 1985

[6]

Neutrophil priming by lipopoly saccharide involves heterogeneity in calcium-midiated signaltransduction.Studies using fluo-3 and flow cytometry. Yee J,Christou NV. J Immunol . 1993

[7]

Theformation of a stature with the features of synovial liningby subcutaneous injection of air: an in vivo tissue culturesystem. Edwards JCW,Sedgwick AD,Willoughby DA. Journal of Paleopathology . 1981

[8]

Effects of Panax notoginseng saponins on the tea-influx andefflux induced by activation of α-1s adrenoceptor of vascularsmooth muscle. Guan YY,Chen KM,Sun JJ,Kwan CY,Daniel EE. Chinese Pharmacological Bulletin . 1990

[9]

Anti-inflammatory effects of totalsaponins of Panax notoginseng. Hao Co,Yang F. Acta Pharmacological Sinica . 1986

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