别嘌呤醇对急性心肌梗死患者心功能、内皮功能、炎症指标的影响

被引：4

作者：

宋巧凤

张立华

王希柱

刘春容

贾红娟

机构：

[1] 华北煤炭医学院附属唐山市人民医院心内科

来源：

中国药房 | 2006年 / 24期

关键词：

高尿酸血症; 别嘌呤醇; 左室收缩功能; 血流依赖性舒张功能; 血管性假性血友病因子; C反应蛋白;

D O I：

暂无

中图分类号：

R542.22 [];

学科分类号：

1002 ; 100201 ;

摘要：

目的:观察应用别嘌呤醇控制高尿酸血症对急性心肌梗死患者心功能、内皮功能及炎症指标的影响。方法:98例急性心肌梗死伴高尿酸血症患者随机分为治疗组与对照组。治疗组采用饮食控制加别嘌呤醇治疗,对照组仅采用饮食控制,疗程均为6wk,观察2组治疗前、后心功能、内皮功能及炎症指标的变化。结果:治疗组血尿酸降低明显(t=2.317,P=0.046);治疗组左室射血分数、血流依赖性舒张功能较对照组改善明显(t=—2.106,P=0.073;t=—3.47,P=0.007);治疗组C反应蛋白较对照组降低明显(t=4.78,P=0.002)。结论:别嘌呤醇可降低血清尿酸,改善血管内皮功能、心功能及炎症反应。

引用

页码：1883 / 1884

页数：2

共 8 条

[1]

Eccher C,Purin B,Pisanelli DM,et al.The case of hea-rt failure. Computers in Biology and Medicine . 2006

[2]

Kalantar-Zadeh K,Abbott KC,Kronenberg F,et al.Epidemiology of dialysis patients and heart failure pa-tients. Seminars in Nephrology . 2006

[3]

Struthers AD,Donnan PT,Lindsay P,et al.Effect of allopurinol on mortality and hospitalizations in chronic heart failure:a retrospective cohort study. Heart . 2002

[4]

Futterman LG,Lemerg L.Fifty percent of patients wi-th coronary artery disease do not have any of the con-ventian risk factors. American Journal of Critical Care . 1998

[5]

Doehner W,Anker SD.Uric acid in chronic heart fail-ure. Seminars in Nephrology . 2005

[6]

Bickel C,Rupprecht HJ,Blankenberg S,et al.Serum uric acid as an independent predictor of mortality in patients with angiographically proven coronary artery disease. The American Journal of Cardiology . 2002

[7]

Mellin V,Isabelle M,Oudot A,et al.Transient reduct-ion in myocardial free oxygen radical levels is involved in the i mproved cardiac function and structure after long-termallopurinol treat ment initiated in establish-ed chronic heart failure. European Heart Journal . 2005

[8]

Koji ma S,Sakamoto T,Ishihara M,et al.Prognostic usefulness of serumuric acid after acute myocardial in-farction. The Japanese Acute Coronary Syndrome Study AmJ Cardiol . 2005

← 1 →