再生障碍性贫血患者淋巴细胞表型变化

被引：7

作者：

傅晋翔

於葛华

张学光

机构：

[1] 苏州大学第二附属医院

[2] 苏州大学生物技术研究所 (导师 )

来源：

中华微生物学和免疫学杂志 | 2002年 / 02期

关键词：

再生障碍性贫血; 淋巴细胞异常活化; 细胞表型变化;

D O I：

暂无

中图分类号：

R556 [贫血病];

学科分类号：

1002 ; 100201 ;

摘要：

目的　研究再生障碍性贫血 (AA)患者骨髓 (BM)及外周血 (PB)淋巴细胞及其活化相关分子的表达及临床意义。方法　采用单色和双色免疫荧光标记法、流式细胞仪分析AA患者的BM和PB中淋巴细胞膜分子的表达。结果　AA患者BM和BP中CD8+细胞增加 ,CD4 CD8比例下降 ,BM中CD2 5 +细胞和HLA DR+细胞增多 ,急性AA增加尤为显著 (P <0 .0 1) ,BM中CD16 +或CD5 6 +细胞也明显增多 (P <0 .0 5 ) ;双标记分析提示T细胞主要为CD8+细胞 ;急性AA患者CD8+ CD2 5 +细胞显著增多 (P <0 .0 1) ,AA患者BM中淋巴细胞活化相关分子表达增多 ,尤其是 4 1BB+、CD95L+和CD40L+细胞显著增多 (P <0 .0 1)。结论　AA患者BM中淋巴细胞活化相关膜分子增多 ,是AA免疫功能异常及最终导致造血功能衰竭的原因之一

引用

页码：36 / 39

页数：4

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