长期应用托吡酯、丙戊酸钠对于血脂水平的影响

被引：5

作者：

夏曼 ^{[1
]}

郁金泰 ^{[2
]}

谭兰 ^{[3
,2
]}

机构：

[1] 潍坊医学院

[2] 青岛大学医学院附属青岛市市立医院神经内科

[3] 潍坊潍坊医学院

来源：

中国卒中杂志 | 2013年 / 8卷 / 10期

关键词：

托吡酯; 丙戊酸钠; 血脂;

D O I：

暂无

中图分类号：

R742.1 [癫痫];

学科分类号：

100204 [神经病学];

摘要：

目的观察长期应用托吡酯、丙戊酸钠单药治疗对癫痫患者血脂水平的影响。方法连续入组长期单药应用丙戊酸钠控制良好的癫痫患者28例、单药应用托吡酯控制良好的癫痫患者30例,并选取健康对照60例,观察各组间血脂代谢指标的差异。结果丙戊酸钠组血清脂蛋白(a)水平显著高于托吡酯组(P<0.001)及健康对照组(P=0.003),而总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯水平较其他两组无明显差异。托吡酯组的总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、脂蛋白(a)、甘油三酯水平较对照组均未有显著差异。结论长期单药应用丙戊酸钠有可能增加癫痫患者脂蛋白(a)的水平,而长期单药应用托吡酯对于血脂水平影响并不明显。

引用

页码：786 / 790

页数：5

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