单核细胞趋化蛋白-1与心肌缺血再灌注损伤的关系

被引:4
作者
程希富
马康华
机构
[1] 重庆医科大学附属第一医院心血管内科
关键词
缺血再灌注; 缺血再灌注损伤; 单核细胞趋化蛋白-1;
D O I
暂无
中图分类号
R363 [病理生理学];
学科分类号
100104 ;
摘要
心肌缺血/再灌注损伤是一个重要的临床问题,而临床上对心肌缺血/再灌注损伤的防治尚缺乏有效的方法。近年发现单核细胞趋化蛋白-1在心肌缺血再灌注的早期出现并呈动态变化,抑制其出现和发展会影响心肌缺血再灌注动物的表现和预后。对单核细胞趋化蛋白-1进行干预可能成为未来新的治疗方向。
引用
收藏
页码:243 / 245
页数:3
相关论文
共 8 条
[1]   Attenuation of cardiac dysfunction by a PPAR-α agonist is associated with down-regulation of redox-regulated transcription factors [J].
Ichihara, Sahoko ;
Obata, Koji ;
Yamada, Yoshiji ;
Nagata, Kohzo ;
Noda, Akiko ;
Ichihara, Gaku ;
Yamada, Akira ;
Kato, Tomoko ;
Izawa, Hideo ;
Murohara, Toyoaki ;
Yokota, Mitsuhiro .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2006, 41 (02) :318-329
[2]   Monocyte chemoattractant protein-1 induces a novel transcription factor that causes cardiac myocyte apoptosis and ventricular dysfunction [J].
Zhou, Limei ;
Azfer, Asim ;
Niu, Jianli ;
Graham, Sarabeth ;
Choudhury, Mahua ;
Adamski, Frances M. ;
Younce, Craig ;
Binkley, Phillip F. ;
Kolattukudy, Pappachan E. .
CIRCULATION RESEARCH, 2006, 98 (09) :1177-1185
[3]  
HMG-CoA Reductase Inhibition Reduces Monocyte CC Chemokine Receptor 2 Expression and Monocyte Chemoattractant Protein-1–Mediated Monocyte Recruitment In Vivo[J] . Ki Hoon Han,Jewon Ryu,Kyung Hee Hong,Jesang Ko,Youngmi Kim Pak,Jae-Bum Kim,Seong Wook Park,Jae Joong Kim.Circulation . 2005 (11)
[4]   Inflammation and angiotensin II [J].
Suzuki, Y ;
Ruiz-Ortega, M ;
Lorenzo, O ;
Ruperez, M ;
Esteban, V ;
Egido, J .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2003, 35 (06) :881-900
[5]   Overexpression of monocyte chemoattractant protein 1 in the brain exacerbates ischemic brain injury and is associated with recruitment of inflammatory cells [J].
Chen, Y ;
Hallenbeck, JM ;
Ruetzler, C ;
Bol, D ;
Thomas, K ;
Berman, NEJ ;
Vogel, SN .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2003, 23 (06) :748-755
[6]  
Membrane-permeable radical scavengers (tempol) for shock, ischemia-reperfusion injury, and inflammation[J] . Christoph Thiemermann.Critical Care Medicine . 2003 (1 Su)
[7]   Induction of monocyte chemoattractant protein-1 in the small veins of the ischemic and reperfused canine myocardium [J].
Kumar, AG ;
Ballantyne, CM ;
Michael, LH ;
Kukielka, GL ;
Youker, KA ;
Lindsey, ML ;
Hawkins, HK ;
Birdsall, HH ;
MacKay, CR ;
LaRosa, GJ ;
Rossen, RD ;
Smith, CW ;
Entman, ML .
CIRCULATION, 1997, 95 (03) :693-700
[8]  
ANTIOXIDANTS AND REDOX SIGNALING[C]. Dipak K.Das.The Second International Symposium on Natural Antioxidants: Molecular Mechanisms and Health Effects,1600