非那甾胺醇质体的体外经皮渗透研究

被引：11

作者：

饶跃峰

郦锋

梁文权

机构：

[1] 浙江大学药学院,浙江大学药学院,浙江大学药学院浙江杭州,浙江杭州,浙江杭州

来源：

中国药学杂志 | 2004年 / 12期

关键词：

非那甾胺; 醇质体; 脂质体; 经皮渗透;

D O I：

暂无

中图分类号：

R943.43 [];

学科分类号：

100602 ; 100702 ;

摘要：

目的考察醇质体作为非那甾胺经皮给药载体的渗透特性。方法分别采用注入法和薄膜分散法制备非那甾胺醇质体(ethosomes)和脂质体;用透射电镜观察所得醇质体和脂质体的形态;采用改良的TK-6A型Franz扩散池,用人皮进行体外经皮渗透实验;以HPLC测定一定时间点接受室中药物浓度,求算累积渗透量及稳态透皮速率,并测定药物在表皮层和真皮层中的滞留量。结果非那甾胺醇质体经皮渗透速率(134μg·cm-2·h-1)是其水饱和溶液的74倍,是脂质体的32倍,是30%乙醇溶液的26倍。24h时药物在皮肤中滞留量大小顺序为醇质体>30%乙醇溶液>脂质体>水饱和液。结论醇质体能显著促进脂溶性药物非那甾胺的经皮渗透,增加药物在皮肤中的蓄积,有望成为一类新型的皮肤给药制剂。

引用

页码：43 / 45

页数：3

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