细菌生物膜与抗生素耐药

被引：19

作者：

宋志军

吴红

Michael Givskov

NielsHφiby

机构：

[1] Department of Clinical Microbiology,University Hospital of Copenhagen,Department of Clinical Microbiology,University Hospital of Copenhagen,BioCentrum-DTU,Technical University of Denmark,Department of Clinical Microbiology,University Hospital of Copenhagen

[2] 广西医科大学,南宁 ,DK- Copenhagen,Denmark

[3] 广西医科大学,南宁 ,DK- Lyngby,Denmark,DK-

来源：

自然科学进展 | 2003年 / 10期

关键词：

细菌生物膜; 慢性感染; 抗生素耐药; 细菌群体感应;

D O I：

暂无

中图分类号：

R378 [病原细菌];

学科分类号：

摘要：

抗生素耐药已成为一个全球关注的严重问题,也是科学界研究的热点问题.近年来的研究成果揭示,抗生素的耐药问题除了与耐药菌株的大量产生有关外,还与致病菌在人体内以生物膜(biofilms)的方式生长密切相关.生物膜是细菌粘附在物体表面上形成的一种具有高度结构性的膜状复合物,其主要成分为细菌分泌的胞外基质和细菌菌体.生物膜的形成显著增强了生物膜内细菌对抗生素、化学杀菌剂以及机体免疫系统的抵抗能力.结合国外近年来的研究成果,介绍了生物膜的发生发展,阐述了对人类健康的危害,重点讨论了细菌生物膜类感染难以根除的原因和对抗生素耐药的可能机制,并根据其特性对细菌生物膜类感染的防治提出一些看法.

引用

页码：9 / 15

页数：7

共 12 条

[1] Biofilms and infection in dialysis patients [J].

Dasgupta, MK .

SEMINARS IN DIALYSIS, 2002, 15 (05) :338-346

[2] Is there a role for quorum sensing signals in bacterial biofilms? [J].

Kjelleberg, S ;

Molin, S .

CURRENT OPINION IN MICROBIOLOGY, 2002, 5 (03) :254-258

[3]

New developments in tetracycline antibiotics: glycylcyclines and tetracycline efflux pump inhibitors[J] . Ian Chopra.Drug Resistance Updates . 2002 (3)

[4]

Pathogenesis of catheter‐related infections: lessons for new designs[J] . A.Pascual.Clinical Microbiology and Infection . 2002 (5)

[5] Control of the AcrAB multidrug efflux pump by quorum-sensing regulator SdiA [J].

Rahmati, S ;

Yang, S ;

Davidson, AL ;

Zechiedrich, EL .

MOLECULAR MICROBIOLOGY, 2002, 43 (03) :677-685

[6] Pseudomonas aeruginosa and the in vitro and in vivo biofilm mode of growth [J].

Hoiby, N ;

Johansen, HK ;

Moser, C ;

Song, ZJ ;

Ciofu, O ;

Kharazmi, A .

MICROBES AND INFECTION, 2001, 3 (01) :23-35

[7] Cystic fibrosis pathogenesis and the role of biofilms in persistent infection [J].

Costerton, JW .

TRENDS IN MICROBIOLOGY, 2001, 9 (02) :50-52

[8] Airway biofilm disease [J].

Kobayashi, P .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2001, 17 (05) :351-356

[9]

Biofilms in peritoneal dialysis[J] . MK Dasgupta,M Larabie.Peritoneal Dialysis International . 2001 (Supp)

[10] The development of bacterial biofilms on indwelling urethral catheters [J].

Morris, NS ;

Stickler, DJ ;

McLean, RJC .

WORLD JOURNAL OF UROLOGY, 1999, 17 (06) :345-350

← 1 2 →