老年急性冠脉综合征患者血清sICAM-1、sVCAM-1变化及影响因素和瑞舒伐他汀的干预作用

被引：11

作者：

潘凌云

朱贵月

马晓静

王勇

苑海涛

唐元升

崔连群

朱兴雷

机构：

[1] 山东大学附属省立医院心内科

来源：

中国老年学杂志 | 2011年 / 31卷 / 01期

关键词：

瑞舒伐他汀; 急性冠状动脉综合征; 可溶性细胞黏附分子; 危险因素;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

1002 ; 100201 ;

摘要：

目的检测老年急性冠脉综合征(ACS)患者血清可溶性细胞间黏附分子-1(sICAM-1)和血管细胞黏附分子-1(sVCAM-1)水平,观察血压、血糖、血脂与血清sICAM-1和sVCAM-1的相关性及早期应用瑞舒伐他汀对血清sICAM-1和sVCAM-1的影响,探讨他汀药物降低ACS炎症反应的可能机制。方法 112例老年冠心病患者稳定性心绞痛(SAP)组36例,ACS组76例,将后者分为常规治疗组、瑞舒伐他汀组。用ELISA法测定老年ACS患者入院后第1、3、5、7天和2 w后sICAM-1和sVCAM-1浓度,用常规治疗方法作为对照,观察瑞舒伐他汀对其sICAM-1和sVCAM-1水平的影响。另根据ACS患者是否有高血压、糖尿病、高血脂病史,分析其与血清sICAM-1和sVCAM-1关系。常规测量血压,测定血糖、血脂,分析其与sI-CAM-1和sVCAM-1的相关性。结果老年ACS患者入院时血清sICAM-1和sVCAM-1浓度比SAP组明显增高(P<0.01)。ACS患者高血压组较正常血压组、糖尿病组较非糖尿病组、高血脂组较正常血脂组血清sICAM-1、sVCAM-1水平明显增高(P均<0.01)。ACS患者血清sICAM-1和sVCAM-1与LDL-C呈正相关(P<0.01),与心率、收缩压、舒张压、TC、HDL-C、TG、FBG、HbA1C无显著相关性(P>0.05)。ACS患者瑞舒伐他汀组较常规治疗组血清sICAM-1和sVCAM-1水平下降显著(P<0.01)。结论 ACS患者血清sICAM-1、sVCAM-1水平升高,炎症反应增强;高血压、糖尿病、高血脂导致的血管内皮损伤是血清sICAM-1、sVCAM-1水平升高的重要因素;瑞舒伐他汀可以降低炎症反应,在ACS的早期治疗中起重要作用。

引用

页码：38 / 40

页数：3

共 10 条

[1]

Pressure Promotes Monocyte Adhesion to the Vascular Wall. Riou S,Mees B,Esposito B, et al. Circulation Research . 2007

[2]

Atherosclerosis[P]. DONG CHUNMING;GOLDSCHMIDT PASCAL J.中国专利:US2008095751A1,2008-04-24

[3]

Circulating soluble adhesion molecules ICAM-1 and VCAM-1 and their association with clinical outcome,troponin T and C-reactive protein in patients with acute coronary syndromes. Postadzhiyan AS,Tzontcheva AV,Kehayov I,et al. Clinical Biochemistry . 2008

[4]

Effect of intensive statin ther-apy on clinical outcomes among patients undergoing percutaneous coro-nary intervention for acute coronary syndrome.PCI-PROVE IT:APROVE IT-TIMI 22 (Pravastatin or Atorvastatin Evaluation and Infec-tion Therapy-Thrombolysis I. Gibson CM,Pride YB,Hochberg CP,et al. Journal of the American College of Cardiology . 2009

[5]

Effects of statins on endothelial func-tion in patients with coronary artery disease〔J〕. Simova II,Denchev SV,Dimitrov SI. Clinical Cardiology . 2009

[6]

Serum adhesion molecule levels in acute coronary syndrome amongIndonesian patients〔J〕. Alwi I. Acta Med Indones . 2008

[7]

Atherosclerosis[P]. DONG CHUNMING;GOLDSCHMIDT PASCAL J.中国专利:US2008095751A1,2008-04-24

[8]

Relation of abdominal fat depots tosystemic markers of inflammation in type 2 diabetes〔J〕. Sam S,Haffner S,Davidson MH,et al. Diabetes Care . 2009

[9]

Markers of inflammation,thrombosis endothelial activation correlate with carotid IMT regression in stable coronary disease after atorvastatin treatment. Baldassarre,D.et al. Nutrition Metabolism and Cardiovascular Diseases . 2009

[10]

Diurnal variation of soluble E- and P-selectin, and intercellular adhesion molecule-1 in patients with and without coronary artery disease. Osmancik,-P,Kvasnicka,-J,Widimsky,-P,et al. Cardiology . 2004

← 1 →