血清内脂素、白介素6与非酒精性脂肪性肝病关系的研究

被引：6

作者：

沈璐

机构：

[1] 江苏省常州市中医医院消化内科

来源：

中国现代医药杂志 | 2013年 / 15卷 / 12期

关键词：

非酒精性脂肪肝; 内脂素; 白介素6; 胰岛素抵抗;

D O I：

暂无

中图分类号：

R575.5 [肝代谢障碍];

学科分类号：

1002 ; 100201 ;

摘要：

目的探讨内脂素、白介素6与非酒精性脂肪性肝病(NAFLD)和胰岛素抵抗(IR)的关系。方法测定60例NAFLD患者及50例健康对照者的空腹血糖(FPG)、空腹胰岛素(FIns)、内脂素(visfatin)、白介素6(IL-6)浓度,计算胰岛素抵抗指数(HOMA-IR)。结果 NAFLD组患者血清内脂素、白介素6水平均高于对照组(P<0.05);两者与胰岛素抵抗指数呈明显正相关(P<0.05),且血清内脂素水平与白介素6水平呈正相关(P<0.05)。结论血清内脂素、白介素6通过与IR相关参与NAFLD的发生和发展。

引用

页码：67 / 68

页数：2

共 7 条

[1] 非酒精性脂肪性肝病诊疗指南 [J].

Fatty Liver and Alcoholic Liver Disease Study Group of the Chinese Liver Disease Association. .

中华肝脏病杂志, 2006, (03) :161-163

[2] Adipokines and cytokines in non-alcoholic fatty liver disease [J].

Jarrar, M. H. ;

Baranova, A. ;

Collantes, R. ;

Ranard, B. ;

Stepanova, M. ;

Bennett, C. ;

Fang, Y. ;

Elariny, H. ;

Goodman, Z. ;

Chandhoke, V. ;

Younossi, Z. M. .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2008, 27 (05) :412-421

[3]

Visfatin, an adipocytokine with proinflammatory and immunomodulating properties.[J] . Moschen Alexander R,Kaser Arthur,Enrich Barbara,Mosheimer Birgit,Theurl Milan,Niederegger Harald,Tilg Herbert. Journal of immunology (Baltimore, Md. : 1950) . 2007 (3)

[4]

Signalling links in the liver: Knitting SOCS with fat and inflammation[J] . Geoffrey C. Farrell. Journal of Hepatology . 2005 (1)

[5]

Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin[J] . Atsunori Fukuhara,Morihiro Matsuda,Masako Nishizawa,Katsumori Segawa,Masaki Tanaka,Kae Kishimoto,Yasushi Matsuki,Mirei Murakami,Tomoko Ichisaka,Hiroko Murakami,Eijiro Watanabe,Toshiyuki Takagi,Megumi Akiyoshi,Tsuguteru Ohtsubo,Shinji Kihara,Shizuya Yamashita,Makoto Makishima,Tohru Funahashi,Shinya Yamanaka,Ryuji Hiramatsu,Yuji Matsuzawa,Iichiro Shimomura. Science . 2005 (5708)

[6]

Insulin resistance and the pathogenesis of nonalcoholic fatty liver disease[J] . Jayanta Choudhury,Arun J. Sanyal. Clinics in Liver Disease . 2004 (3)

[7]

Hormonal regulation of the novel adipocytokine visfatin in 3T3-L1 adipocytes .2 Kralisch Susan,Klein Johannes,Lossner Ulrike,Bluher Matthias,Paschke Ralf,Stumvoll Michael,Fasshauer Mathias. The Journal of endocrinology . 2005

← 1 →