Toll样受体信号通路与骨关节炎相关性的研究进展

被引：14

作者：

温家宾

沈彬

机构：

[1] 四川大学华西医院骨科

来源：

中国矫形外科杂志 | 2012年 / 20卷 / 13期

关键词：

Toll样受体; 骨关节炎; 研究进展;

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

<正>骨关节炎(osteoarthritis,OA)又称退行性骨关节病,是由多种因素引起关节软骨纤维化、皲裂、溃疡、脱失而导致的关节疾病,目前已越来越成为医患乃至社会关注的焦点话题。虽然年龄的增长、肥胖、炎症、创伤及遗传等危险因素被广泛接受,但OA明确的病因及发病机制仍需进一步研究探讨[1]。人类Toll样受体(Toll-like receptors,TLR)是近年来发现的一类细胞表面信号转导跨膜受体,在固有免疫中对入侵病原微生物的识别发挥重要作用。目前研究发现,在OA的软骨和滑

引用

页码：1206 / 1208

页数：3

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