从生命科学领域解读《Science》2009年度十大突破

被引：4

作者：

张婷

王晓民

机构：

[1] 首都医科大学神经生物学系首都医科大学北京神经科学研究所,神经变性病学教育部重点实验室

来源：

首都医科大学学报 | 2010年 / 31卷 / 01期

关键词：

雷帕霉素; 热量限制; 基因治疗;

D O I：

暂无

中图分类号：

N49 [普及读物];

学科分类号：

摘要：

2009年12月18日,美国《Science》杂志公布了2009年十大突破,其中生命科学领域占有2席:雷帕霉素和热量限制可延长哺乳动物寿命,基因治疗在多个致命性疾病中获得成功案例。本文主要对以上2项突破进行综述。

引用

页码：136 / 141

页数：6

共 7 条

[1]

Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial[J] . Albert M Maguire,Katherine A High,Alberto Auricchio,J Fraser Wright,Eric A Pierce,Francesco Testa,Federico Mingozzi,Jeannette L Bennicelli,Gui-shuang Ying,Settimio Rossi,Ann Fulton,Kathleen A Marshall,Sandro Banfi,Daniel C Chung,Jessica IW Morgan,Bernd Hauck,Olga Zelenaia,Xiaosong Zhu,Leslie Raffini,Frauke Coppieters,Elfride De Baere,Kenneth S Shindler,Nicholas J Volpe,Enrico M Sura

[2] The scientific basis of caloric restriction leading to longer life [J].

Fontana, Luigi .

CURRENT OPINION IN GASTROENTEROLOGY, 2009, 25 (02) :144-150

[3] Long-term efficacy of enzyme replacement therapy for Adenosine deaminase (ADA)-deficient Severe Combined Immunodeficiency (SCID) [J].

Chan, B ;

Wara, D ;

Bastian, J ;

Hershfield, MS ;

Bohnsack, J ;

Azen, CG ;

Parkman, R ;

Weinberg, K ;

Kohn, DB .

CLINICAL IMMUNOLOGY, 2005, 117 (02) :133-143

[4] Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway [J].

Kapahi, P ;

Zid, BM ;

Harper, T ;

Koslover, D ;

Sapin, V ;

Benzer, S .

CURRENT BIOLOGY, 2004, 14 (10) :885-890

[5]

Long-term survival and transplantation of haemopoietic stem cells for immunodeficiencies: report of the European experience 1968–99[J] . Corinne Antoine,Susanna Müller,Andrew Cant,Marina Cavazzana-Calvo,Paul Veys,Jaak Vossen,Anders Fasth,Carsten Heilmann,Nicolas Wulffraat,Reinhard Seger,Stéphane Blanche,Wilhelm Friedrich,Mario Abinun,Graham Davies,Robert Bredius,Ansgar Schulz,Paul Landais,Alain Fischer.The Lancet . 2003 (9357)

[6] Long-term effect of bone-marrow transplantation for childhood-onset cerebral X-linked adrenoleukodystrophy [J].

Shapiro, E ;

Krivit, W ;

Lockman, L ;

Jambaqué, I ;

Peters, C ;

Cowan, M ;

Harris, R ;

Blanche, S ;

Bordigoni, P ;

Loes, D ;

Ziegler, R ;

Crittenden, M ;

Ris, D ;

Berg, B ;

Cox, C ;

Moser, H ;

Fischer, A ;

Aubourg, P .

LANCET, 2000, 356 (9231) :713-718

[7]

Gene therapy for immunodeficiency due to adenosine deaminase deficiency .2 A Aiuti,F Cattaneo,S Galimberti. N Engl J Med . 2009

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