乳腺癌中pS2、HSP27、Cath-D的表达及临床意义附视频

被引：3

作者：

罗峻

熊永炎

林利

机构：

[1] 武汉大学中南医院病理科

[2] 湖北中医学院附属医院

来源：

肿瘤防治研究 | 2004年 / 02期

关键词：

乳腺癌; pS2; 热休克蛋白27; 组织蛋白酶D;

D O I：

暂无

中图分类号：

R737.9 [乳腺肿瘤];

学科分类号：

100214 ;

摘要：

目的　探讨乳腺癌雌激素调节基因 pS2、HSP2 7、Cath D表达的临床意义。方法　采用免疫组化S -P法检测 50例原发性乳腺浸润性导管癌中ER、pS2、HSP2 7、Cath -D的表达。结果　pS2的表达与ER呈正相关性 (P <0 .0 1) ;与组织学分级呈负相关性 (P <0 .0 5)。HSP2 7表达与淋巴结转移、组织学分级及ER状态无相关性。有淋巴结转移的乳腺癌 ,间质Cath -D高表达率显著高于无淋巴结转移者 (P<0 .0 1)。结论　pS2表达与ER有关 ,pS2确能反映乳腺癌雌激素调节系统的完整性。间质Cath D表达与淋巴结转移有关 ,可作为判断乳腺癌预后的指标

引用

页码：96 / 98

页数：3

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