外源性镁离子对重型颅脑创伤患者的治疗作用

被引：25

作者：

张赛 ^{[1
]}

李建伟 ^{[1
]}

只达石 ^{[2
]}

胡群亮 ^{[1
]}

孙洪涛 ^{[1
]}

机构：

[1] 武警医学院附属医院神经外科

[2] 天津医科大学总医院

来源：

中华神经外科杂志 | 2006年 / 02期

关键词：

硫酸镁; 重型颅脑创伤; 丙二醛; 预后; 临床试验;

D O I：

暂无

中图分类号：

R651.15 [];

学科分类号：

1002 ; 100210 ;

摘要：

目的探讨重型颅脑创伤(sTBI)患者硫酸镁治疗与患者血清丙二醛(MDA)含量及预后的关系。方法 54例人选病例按入院先后随机分为治疗组和对照组。治疗组首先15min内静脉滴注2．5g硫酸镁,接着10g硫酸镁24h持续静滴,连用3天。对照组除硫酸镁外其他治疗完全相同。两组再按人院GCS评分分为特重组(GCS 3—5分)和重型组(GCS 6～8分),住院期间监测患者血清镁和MDA含量,伤后3个月纪录患者GOS评分。结果治疗组MDA含量低于对照组,特重组MDA含量高于重型组,血清镁离子含量低于重型组(P<0．05)。治疗组GOS评分好于对照组, 但没有统计学意义。结论分sTBI患者,伤情越重,血清MDA含量越高,血清镁离子含量越低。硫酸镁能降低sTBI患者血清MDA含量,有改善预后的趋势。

引用

页码：76 / 78

页数：3

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