针灸对肝郁化火型失眠患者NE及PKC,BDNF表达水平的影响

被引：27

作者：

马涛 ^{[1
]}

黄璐 ^{[1
]}

赵阳 ^{[2
]}

朱倩 ^{[3
]}

李焱 ^{[1
]}

机构：

[1] 北京中医药大学第四附属医院枣庄医院针灸科

[2] 枣庄市立医院泌尿外科

[3] 枣庄市立医院骨科

来源：

现代生物医学进展 | 2016年 / 16卷 / 21期

基金：

北京市自然科学基金;

关键词：

针刺; 肝郁化火型失眠; NE; PKC; BDNF;

D O I：

10.13241/j.cnki.pmb.2016.21.018

中图分类号：

R246.6 [神经精神病科];

学科分类号：

100225 [精神医学];

摘要：

目的:探究针刺对肝郁化火型失眠患者血清中去甲肾上腺素(NE)含量及蛋白激酶C(PKC)、脑源性神经营养因子(BDNF)基因表达水平的影响。方法:选取我院针灸科收治失眠,肝郁化火型住院患者,共120例。随机分为两组,对照组60例予以枣仁安神胶囊治疗;治疗组60例,在对照组基础上予以针刺四神聪穴(百会穴前后左右各相去1寸)。检测并比较患者血清中NE含量,RT-PCR检测脑组织中PKC、BDNF基因表达水平。结果:与治疗前相比,两组患者的NE水平均降低,PKC、BDNF水平均升高(P<0.05);与对照组相比,实验组患者的NE水平较低,PKC、BDNF水平较高(P<0.05),实验组患者的治疗总有效率较高(P<0.05)。结论:针刺能够明显降低肝郁化火型失眠患者血清中NE水平,升高脑组织中PKC及BDNF基因转录水平,对临床有指导意义。

引用

页码：4071 / 4074

页数：4

共 10 条

[1]

Correlation between Traditional Chinese Medicine symptom patterns and serum concentration of zinc, iron, copper and magnesium in patients with hepatitis B and associated liver cirrhosis [J].

Teng Lichun ;

Zhang Jiongshan ;

Dal Min ;

Wang Fenglin ;

Yang Hongzhi .

JOURNAL OF TRADITIONAL CHINESE MEDICINE, 2015, 35 (05) :546-550

[2]

针刺对肝郁化火型不寐患者不同神经递质表达的影响.[J].季向东;王群松;朱文娴;.中国针灸.2015, 06

[3]

Curative effect of acupuncture and moxibustion on insomnia: a randomized clinical trial.[J].Xiyan Gao;Cuixiang Xu;Peiyu Wang;Shan Ren;Yanli Zhou;Xuguang Yang;Ling Gao;.Journal of Traditional Chinese Medicine.2013, 04

[4]

Research Progress of Acupuncture-moxibustion for Insomnia: An Analysis of Literature in Recent 5 Years.[J].Fang Chao-jun;Yang Wen-jia;Chen Yun-fei;.Journal of Acupuncture and Tuina Science.2013, 03

[5]

Clinical Research of Acupuncture on Malignant Tumor Patients for Improving Depression and Sleep Quality [J].

Feng Yu ;

Wang Xin-yu ;

Li Shao-dan ;

Zhang Yin ;

Wang Hai-ming ;

Li Min ;

Cao Ke ;

Ye Yu-fei ;

Zhang Zhao .

JOURNAL OF TRADITIONAL CHINESE MEDICINE, 2011, 31 (03) :199-202

[6]

Integrating acupuncture into cancer care.[J].Tsai-Ju Chien;Chia-Yu Liu;Chung-Hua Hsu.Journal of Traditional and Complementary Medicine.2013, 4

[7]

A comparison between acupuncture versus zolpidem in the treatment of primary insomnia.[J].Jung-Hung Tu;Wei-Ching Chung;Chun-Yuh Yang;Dong-Sheng Tzeng.Asian Journal of Psychiatry.2011, 3

[8]

Acupuncture improves sleep in postmenopause in a randomized; double-blind; placebo-controlled study.[J].Hachul;Garcia;Maciel;Yagihara;Tufik;Bittencourt.Climacteric.2012, 1

[9]

Acupuncture for insomnia? An overview of systematic reviews [J].

Ernst, Edzard ;

Lee, Myeong Soo ;

Choi, Tae-Young .

EUROPEAN JOURNAL OF GENERAL PRACTICE, 2011, 17 (02) :116-123

[10]

A systematic review of insomnia and complementary medicine.[J].Jerome Sarris;Gerard J. Byrne.Sleep Medicine Reviews.2010, 2

← 1 →