麦冬皂苷D对过氧化氢造模的HUVEC保护作用机制研究

被引:21
作者
蒋凤荣
张旭
洪艳丽
机构
[1] 南京中医药大学病理系
关键词
麦冬皂苷D; 过氧化氢; HUVEC; 作用机制;
D O I
10.13241/j.cnki.pmb.2008.09.025
中图分类号
R285.5 [中药实验药理];
学科分类号
1008 ;
摘要
目的:研究麦冬皂苷D对HUVEC凋亡相关分子的影响,探讨其作用机制。方法:用H2O2构建凋亡模型,运用MTT及流式细胞仪检测细胞活性,激光共聚焦方法测定粒体膜电位和钙离子浓度。结果:麦冬皂苷D可以稳定线粒体膜电位,减少钙离子内流,增加细胞的活力。结论:麦冬皂苷D对HUVEC有一定的保护作用。
引用
收藏
页码:1646 / 1648
页数:3
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