Wnt/β-catenin信号通路及与之相关骨质疏松药物研究

被引：15

作者：

楼超

陈鸿亮

徐华梓

机构：

[1] 温州医科大学附属第二医院骨科

来源：

中国骨质疏松杂志 | 2014年 / 20卷 / 01期

关键词：

Wnt/β-catenin信号通路; Sclerostin; 骨质疏松; 药物;

D O I：

暂无

中图分类号：

R977.1 [激素类药物];

学科分类号：

100710 [药物代谢动力学];

摘要：

目的 Wnt/β-catenin信号通路在维持骨组织平衡过程中发挥至关重要的作用,主要通过调节信号通路过程中的三类抑制物实现,分别为Sclerostin、Dickkopfs(DKKs)、Secreted frizzled-related proteins(SFRPs)。同时,与之相关的促进骨形成的新药,如Sclerostin单克隆抗体(AMG 785)和DKK1单克隆抗体(RH2-18),正在进行动物及III期临床试验。本文就Wnt/β-catenin信号通路的结构及分布,该通路及其调节机制对骨代谢的作用及与之相关的骨质疏松药物研究作一综述。

引用

页码：78 / 83

页数：6

共 20 条

[1]

The Role of Dkk1 in Bone Mass Regulation: Correlating Serum Dkk1 Expression with Bone Mineral Density [J].

Butler, Joseph S. ;

Murray, David W. ;

Hurson, Conor J. ;

O'Brien, Julie ;

Doran, Peter P. ;

O'Byrne, John M. .

JOURNAL OF ORTHOPAEDIC RESEARCH, 2011, 29 (03) :414-418

[2]

Single‐dose; placebo‐controlled; randomized study of AMG 785; a sclerostin monoclonal antibody.[J].DesmondPadhi;GrahamJang;BrianStouch;LiangFang;EdwardPosvar.J Bone Miner Res.2010, 1

[3]

Wnt signalling mediates the cross-talk between bone marrow derived pre-adipocytic and pre-osteoblastic cell populations.[J]..Experimental Cell Research.2010, 6

[4]

LRP4 Mutations Alter Wnt/β-Catenin Signaling and Cause Limb and Kidney Malformations in Cenani-Lenz Syndrome [J].

Li, Yun ;

Pawlik, Barbara ;

Elcioglu, Nursel ;

Aglan, Mona ;

Kayserili, Huelya ;

Yigit, Goekhan ;

Percin, Ferda ;

Goodman, Frances ;

Nuernberg, Gudrun ;

Cenani, Asim ;

Urquhart, Jill ;

Chung, Boi-Dinh ;

Ismail, Samira ;

Amr, Khalda ;

Aslanger, Ayca D. ;

Becker, Christian ;

Netzer, Christian ;

Scambler, Pete ;

Eyaid, Wafaa ;

Hamamy, Hanan ;

Clayton-Smith, Jill ;

Hennekam, Raoul ;

Nuernberg, Peter ;

Herz, Joachim ;

Temtamy, Samia A. ;

Wollnik, Bernd .

AMERICAN JOURNAL OF HUMAN GENETICS, 2010, 86 (05) :696-706

[5]

The effect of teriparatide on serum Dickkopf-1 levels in postmenopausal women with established osteoporosis [J].

Anastasilakis, Athanasios D. ;

Polyzos, Stergios A. ;

Avramidis, Avraam ;

Toulis, Konstantinos A. ;

Papatheodorou, Athanasios ;

Terpos, Evangelos .

CLINICAL ENDOCRINOLOGY, 2010, 72 (06) :752-757

[6]

Two Doses of Sclerostin Antibody in Cynomolgus Monkeys Increases Bone Formation, Bone Mineral Density, and Bone Strength [J].

Ominsky, Michael S. ;

Vlasseros, Fay ;

Jolette, Jacquelin ;

Smith, Susan Y. ;

Stouch, Brian ;

Doellgast, George ;

Gong, Jianhua ;

Gao, Yongming ;

Cao, Jin ;

Graham, Kevin ;

Tipton, Barbara ;

Cai, Jill ;

Deshpande, Rohini ;

Zhou, Lei ;

Hale, Michael D. ;

Lightwood, Daniel J. ;

Henry, Alistair J. ;

Popplewell, Andrew G. ;

Moore, Adrian R. ;

Robinson, Martyn K. ;

Lacey, David L. ;

Simonet, W. Scott ;

Paszty, Chris .

JOURNAL OF BONE AND MINERAL RESEARCH, 2010, 25 (05) :948-959

[7]

Update in New Anabolic Therapies for Osteoporosis [J].

Canalis, Ernesto .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (04) :1496-1504

[8]

Overexpression of Secreted Frizzled-Related Protein 1 Inhibits Bone Formation and Attenuates Parathyroid Hormone Bone Anabolic Effects [J].

Yao, Wei ;

Cheng, Zhiqiang ;

Shahnazari, Mohammad ;

Dai, Wewei ;

Johnson, Mark L. ;

Lane, Nancy E. .

JOURNAL OF BONE AND MINERAL RESEARCH, 2010, 25 (02) :190-199

[9]

Bone Density Ligand; Sclerostin; Directly Interacts With LRP5 but Not LRP5.[J].Debra L Ellies;Beth Viviano;John McCarthy;Jean‐Philippe Rey;Nobue Itasaki;Scott Saunders;Robb Krumlauf PhD.Journal of Bone and Mineral Research.2006, 11

[10]

A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation [J].

Bodine, Peter V. N. ;

Stauffer, Barbara ;

Ponce-de-Leon, Helga ;

Bhat, Ramesh A. ;

Mangine, Annamarie ;

Seestaller-Wehr, Laura M. ;

Moran, Robert A. ;

Billiard, Julia ;

Fukayama, Shoichi ;

Komm, Barry S. ;

Pitts, Keith ;

Krishnamurthy, Girija ;

Gopalsamy, Ariamala ;

Shi, Mengxiao ;

Kern, Jeffrey C. ;

Commons, Thomas J. ;

Woodworth, Richard P. ;

Wilson, Matthew A. ;

Welmaker, Gregory S. ;

Trybulski, Eugene J. ;

Moore, William J. .

BONE, 2009, 44 (06) :1063-1068

← 1 2 →