高同型半胱氨酸血症与脑梗死及帕金森病关系的探讨

被引：12

作者：

傅毅

陈生弟

陆国强

机构：

[1] 上海市瑞金医院神经内科,上海市瑞金医院神经内科,上海市瑞金医院神经内科,,

来源：

中国微循环 | 2003年 / 04期

关键词：

脑梗死; 帕金森病; 同型半胱氨酸; 叶酸; 维生素B12;

D O I：

暂无

中图分类号：

R743.33 [脑栓塞];

学科分类号：

摘要：

目的探讨高同型半胱氨酸 (Hcy)血症与脑梗死、帕金森病 (PD)的关系。方法选择年龄及性别基本匹配的脑梗死组60例、PD组15例和正常老年组30例 ,采用酶联免疫分析法测定被检者血浆Hcy浓度 ,并同时测定叶酸和维生素B12。结果脑梗死组和PD组的血Hcy浓度分别是 (17.15±4.63)μmol/L、(15.65±2.70) μmol/L ,明显高于正常老年组 (10.12±2.62) μmol/L。另外 ,经相关回归分析示 :被检者血中Hcy水平与叶酸、维生素B12 存在负相关。结论脑梗死组、PD组及正常老年组之间血中Hcy水平不尽相同。Hcy水平与脑梗死、PD的发生有一定联系 ,并与叶酸、维生素B12 呈负相关。因此补充营养元素叶酸、维生素B12 可能有助于降低Hcy水平及其危险因素。

引用

页码：211 / 213

页数：3

共 12 条

[1]

A meta_analysis of cerebrovascular and hyperhomocysteinemia. Moller J,Nielsen GM,Tvedegaard KC,et al. Scandinavian Journal of Clinical and Laboratory Investigation . 2000

[2]

High_normal serum homocysteine concentrations are associated with an increased risk of early atherosclerotic carotid artery wall lesions in healthy subjects. Willnek WK,Ludwing M,Lennarz M,et al. Journal of Hypertension . 2000

[3]

Homocysteine, folate deficiency, and Parkinson ’ s disease. Miller JW. Nutrition Reviews . 2002

[4]

Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson ’ s disease. Duan W,Ladenheim B,Cutler RG,et al. Journal of Neurochemistry . 2002

[5]

Hyperhomocysteinemia and hypofibrinolysis in young adults with ischemic stroke. Kristensen B,Malm J,Nilsson TK,et al. Stroke . 1999

[6]

Hyperhomocysteinemia, atheroclerosis and thrombosis. Cattaneo M. Thrombosis and Haemostasis . 1999

[7]

Vascular pathology of homocysteinemia: Implications for the pathogenesis of arteriosclerosis. McCully KS. American Journal of Pathology . 1969

[8]

Elevated plasma homocysteine levels in patients treated with levodopa: association with vascular disease. Rogers JD,Sanchez_Saffon A,Frol AB,et al. Archives of Neurology . 2003

[9]

Relation of plasma homocysteine to cerebral infarction and cerebral atherosclerosis. Yoo JH,Chung CS,Kang SS. Stroke . 1998

[10]

Relationship between homocysteine and thrombotic disease. Selhub J,D ’ Angelo A. The American Journal of The Medical Sciences . 1998

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