维持性血液透析患者血清瘦素水平与营养状况的关系

被引：9

作者：

汪年松

王蕾

唐令诠

机构：

[1] 上海交通大学第六人民医院肾内科

[2] 上海交通大学第六人民医院检验科

来源：

上海第二医科大学学报 | 2005年 / 01期

关键词：

血液透析; 瘦素; 营养不良;

D O I：

暂无

中图分类号：

R692.5 [肾功能衰竭];

学科分类号：

摘要：

目的探讨尿毒症血液透析患者血清瘦素(leptin)水平与营养状况的关系。方法血透组患者60例和正常对照组20例为研究对象,采用ELISA法测定血清leptin水平,同时测定肾功能、前白蛋白、白蛋白、补体、转铁蛋白、血脂,并运用人体学测定和主观全面营养评估法(SGA)评价受试者的营养状况。结果血透组患者血清leptin水平为(34.2±13.4)μg/L,显著高于对照组的(14.3±6.8)μg/L(P<0.01));血透组患者血清前白蛋白、白蛋白、转铁蛋白、补体和人体学指标等客观营养指标均低下,且与血清leptin水平呈显著负相关;SGA评估显示血透组患者存在营养不良,且营养状况越差,血浆leptin水平越高。结论血透患者血清leptin水平较健康人显著增高,可能与其营养不良的发病有关。

引用

页码：57 / 59+67 +67

页数：4

共 10 条

[1]

Increased plasma leptin/ fat ratio in patients with chronic renal failure: a cause of malnutrition. Young GA,Woodrow G,Kendall S,et al. Nephrology Dialysis Transplantation . 1997

[2]

Plasma leptin is partly cleared by the kidney and is elevated in hempdialysis patients. Sharma K,Considine RV,Michael B,et al. Kidney International . 1997

[3]

Nutritional status of patients on hemodialysis and peritoneal dialysis. Marckmann P. Clinical Nephrology . 1988

[4]

The Ob protein and the kidney. Sharma K,Considine RV. Kidney International . 1998

[5]

Factors predicting malnutrition in hemodialysis patients: a cross-sectional study. Qureshi AR,Alvestrand A,Danielsson A,et al. Kidney International . 1998

[6]

Free serum leptin but not bound leptin concentration are elevated in patients with end stage renal disease. Wadjaja A,Kielstein JT,Lee SW,et al. Nephrology Dialysis Transplantation . 2000

[7]

Serum immuno-reactive leptin concentration and its relation to the body fat content in chronic renal failure. Hemburger O,Lonnqvist F,Danielsson A,et al. Journal of the American Society of Nephrology . 1997

[8]

Increased plasma leptin concentration in end-stage renal disease. Merabet E,Dagogo JS,Coyne,et al. Journal of Clinical Endocrinology and Metabolism . 1997

[9]

Positional cloning of the mouse obese gene and its human homologue. Zhang Y,Poenca R,Maffei M,et al. Nature . 1994

[10]

Leptin: the weight-reducing plasma protein encoded by the obese gene. Wolf G. Nutrition Reviews . 1996

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