血胆固醇与脑胆固醇关系的研究

被引：5

作者：

朱海暴

石如玲

赵朝贤

杨原

王素玲

姜玲玲

机构：

[1] 河北医科大学生化教研室

来源：

中国老年学杂志 | 2005年 / 10期

关键词：

胆固醇; 考来烯胺; 邻苯二甲酸二异辛酯; 过氧化物酶体; TC-24S-羟化酶;

D O I：

暂无

中图分类号：

R749.16 [];

学科分类号：

100203 ;

摘要：

目的研究血胆固醇(TC)对脑TC及脑β-淀粉样蛋白(Aβ)生成的影响。方法给高TC血症的W istar大鼠饲喂考来烯胺和邻苯二甲酸二异辛酯(d iethylhexyl phthalate,DEHP)促进胆汁酸的合成,降低其血TC后,测定其脑TC及Aβ的含量;以测定脑羟甲基戊二酰辅酶A还原酶HMG-COAR)和脑TC 24S-羟化酶(CYP46)的mRNA表达水平,反映脑TC的合成水平和转出水平。结果高TC血症大鼠脑Aβ含量明显增高(P<0.05),脑TC以及脑HMG-COAR和CYP46的mRNA表达水平未变;考来烯胺饮食组大鼠血TC水平明显降低(P<0.01),脑中Aβ含量和对照组一样保持在低水平,脑TC的含量有增高趋势,HMG-COAR mRNA表达增加(P<0.05),CYP46 mRNA表达无变化;DEHP饮食组血TC及脑中的Aβ无显著变化,脑TC的含量明显增高(P<0.05),脑HMG-COAR mRNA表达增加(P<0.05),CYP46 mRNA表达降低(P<0.01)。结论脑TC的含量不受血TC的直接影响,而与其自身代谢有关;整体动物脑Aβ生成量增加与脑TC浓度无关。

引用

页码：1208 / 1210

页数：3

共 10 条

[1]

ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain cap illary endothelial cells. Panzenboeck U,Balazs Z,Sovic A,et al. Journal of Biological Chemistry . 2002

[2]

Ontogenesis and regulation of cholesterolmetabolism in the central nervous system of themouse. Quan G,X ie C,D ietschy JM,et al. Brain Research Developmental Brain Research . 2003

[3]

Ontogenesis and regulation of cholesterolmetabolism in the central nervous system of themouse. Quan G,X ie C,D ietschy JM,et al. Brain Research Developmental Brain Research . 2003

[4]

D iet-induced hypercholesterolem ia enhances brain A beta accumulation in transgenic m ice. Shie FS,Jin LW,Cook DG,et al. NeuroReport . 2002

[5]

Hypercholesterolem ia accelerates the A lzheimer ’s amyloid pathology in a transgenic mouse model. Refolo LM,Malester B,LaFrancois J,et al. Neurobiol D is . 2000

[6]

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. M ikael Simons,Patrick Keller,Bart De,et al. Journal of Neurobiology . 1998

[7]

Uptake and transport of highdensity lipoprotein(HDL) and HDL-associated alpha-tocopherol by an in vitro blood-brain barriermodel. Balazs Z,Panzenboeck U,HammerA,et al. Journal of Neurochemistry . 2004

[8]

Investigationgs on the mechanism of the hypocholesterolem ic action of diethylhexyl phthalate in rats. NairN,Kurup CK. Biochemcal Pharmacology . 1986

[9]

Modulation of secreted beta-amyloid precursor protein and amyloid beta-peptide in brain by cholesterol. David SH,Stephen PT,Mary JS,et al. Biochemistry . 1998

[10]

Cholestrolmetabolism in the brain. D ietschy JM,Turley SD. Current Opinion in Lipidology . 2001

← 1 →