新型冠状病毒肺炎发病机制及临床研究进展

被引：52

作者：

闵瑞

刘洁

代喆

孙家忠

邓浩华

李新

吴玉文

黄芪

孙力

杨杪

徐焱成

机构：

[1] 武汉大学中南医院内分泌科

来源：

中华医院感染学杂志 | 2020年 / 30卷 / 08期

关键词：

新型冠状病毒肺炎; 新型冠状病毒; 冠状病毒;

D O I：

暂无

中图分类号：

R563.1 [肺炎];

学科分类号：

100201 [内科学];

摘要：

新型冠状病毒肺炎(Corona virus disease 2019,COVID-19)是由一种新的β冠状病毒-新型冠状病毒(2019 novel coronavirus,2019-nCoV)引起,以血管紧张素转化酶2(Angiotensin converting enzyme 2,ACE2)作为受体侵入细胞导致肺损伤,病情加重与继发引起的全身性炎症反应密切相关,重症患者会出现急性呼吸窘迫综合征(Acute respiratory distress syndrome,ARDS)和感染性休克,最终出现多器官功能衰竭。目前大多数药物如巴利替尼、瑞德西韦、氯喹等尚处于临床试验阶段,尚无特效药治疗。COVID-19传染性强,可引起多种严重的并发症,对全球公共安全造成了极大威胁。研究其病原学及发病机制,进而开展对治疗药物和疫苗的临床研究,对及时控制病毒传播,防止病情恶化进展,减少并发症及病死率具有重大意义。

引用

页码：1171 / 1176

页数：6

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