钙拮抗剂治疗大白鼠吗啡戒断综合征的研究

被引:13
作者
刘屏
陈世铭
应晓
机构
[1] 解放军总医院临床药理研究室
[2] 天津第二医学院药学系
关键词
钙拮抗剂; 吗啡; 成瘾; 戒断综合征; 依赖性; 大白鼠;
D O I
10.13936/j.cnki.cjdd1992.1994.03.006
中图分类号
R749.61 [];
学科分类号
摘要
本文研究主要钙拮抗剂对大白鼠吗啡戒断综合征的治疗效果。选用连续2d给药,催促成瘾的大鼠,给予不同药物治疗。结果表明,钙拮抗剂对大白鼠的吗啡戒断综合征有一定治疗作用。硝苯地平有效剂量为10-80mg·kg-1,其中以20与40mg·kg-1效果较好(P<0.01);尼莫地平50-300 mg·kg-1有效,以100mg·kg-1为佳;维拉帕米20与40mg·kg-1效果较好;硝苯地平与可乐宁合用后的治疗作用优于单独使用时的作用。
引用
收藏
页码:166 / 169
页数:4
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