Gene transfer and therapy with adenoviral vector in rats with diethylnitrosamine-induced hepatocellular carcinoma

被引：1

作者：

Miguel Idoate

Roberto Bilbao

Bruno Sangro

Oscar Bruna

Jesus Vazquez

Jesus Prieto

机构：

[1] Experimental Pathology

[2] University Clinic and School of Medicine

[3] University of Navarra

[4] Pamplona

[5] Spain

[6] Department of Internal Medicine

来源：

实验血液学杂志 | 1997年 / 03期

关键词：

HCC; gene; HSV; GCV;

D O I：

暂无

中图分类号：

R735.7 [肝肿瘤];

学科分类号：

100214 ;

摘要：

<正> Viral-mediated gene transfer of thymidine kinase ofherpes simplex virus (HSV-tk) has been used to confercytotoxic sensitivity to ganciclovir (GCV) in a variety oftnmor cells. HSV-tk converts GCV into a phosphorylatedcompound which is toxic for dividing cells by blockingDNA synthesis. Our previous study has shown that

引用

页码：301 / 302

页数：2