血管内皮生长因子的脑保护及其机制研究进展

被引：14

作者：

王永权

孙凤艳

机构：

[1] 复旦大学上海医学院医学神经生物学系医学神经生物学国家重点实验室

来源：

生理科学进展 | 2007年 / 03期

关键词：

血管内皮生长因子; 脑中风; 神经保护; 神经修复;

D O I：

暂无

中图分类号：

R741 [神经病学];

学科分类号：

100204 [神经病学];

摘要：

血管内皮生长因子(vascular endothelial growth factor,VEGF)是一种重要的血管发育调节因子,最早发现于肿瘤细胞。上世纪90年代,人们发现VEGF在神经细胞上也有广泛表达,并具有神经细胞保护作用。此外,VEGF显著促进成年哺乳动物结构性神经元再生区(constitutive neurogenic regions)和非神经元再生区(non-neurogenic regions)的神经元再生/更新(neurogenesis/regenera-tion),显示了VEGF在神经损伤性及退行性疾病治疗中的潜在意义。本文着重讨论VEGF在脑缺血损伤中的神经保护(neuroprotection)和神经修复(neural repair)及其细胞和分子机制研究进展。

引用

收藏

页码：202 / 207

页数：6

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