肿瘤血管生成与抗血管生成治疗

被引:12
作者
侯恩存
机构
[1] 山东省菏泽市立医院山东菏泽
关键词
肿瘤/治疗; 血管生成;
D O I
10.13455/j.cnki.cjcor.2003.02.039
中图分类号
R730.5 [肿瘤治疗学];
学科分类号
100214 ;
摘要
<正> 恶性肿瘤的死亡率已逐渐占据各种疾病的首位,肿瘤的侵袭性生长和转移又是恶性肿瘤的最重要生物学特性,一般实体瘤在诊断时就有2/3左右已经存在转移,而转移也恰恰是肿瘤治疗失败的主要原因,绝大多数肿瘤患者最终死于转移瘤的生长和毒副作用,因此对肿瘤侵袭和转移的早期诊断和合理治疗是恶性肿瘤治疗取得成功的关键。肿瘤的生长和转移是一个依赖于血管的过程,当肿瘤体积大于2mm3
引用
收藏
页码:89 / 91
页数:3
相关论文
共 15 条
[1]  
Assessment of tumor vascular-ization: immunohistochemical and non-invasive methods. Fanelli M,Locopo N,Gattuso D,et al. International Journal of Biological Markers . 1999
[2]  
Tumor micrometasta-ses; the influence of angingenesis. McDonnell CO,Hill ADK,Mcnamara DA.et al. European Journal of Surgical Oncology . 2000
[3]  
Angiogenesis and cancer metastasis. Fidler IJ. Cancer J Sci Am(United States) . 2000
[4]  
Tumour angiogenesis and tissue factor. Folkman J. Nature Medicine . 1996
[5]  
Tumor angiogenesis: therapeutic implications. Folkman J. The New England Journal of Medicine . 1971
[6]  
Angingenic index: a new method for assessing microvascularity in breast carcinoma with possible prognostic implication. Laforga JB,Aranda FI. Breast Journal . 2000
[7]  
Patterns and emerging mechanisms of the an-giogenic switch during tumorigenesis. Hanahan D,Folkman J. Cell . 1996
[8]  
Tumor angiogenesis as a predictor of recurrence in gastric carcinoma. Maeda K,Chung YS,Takatsuka S,et al. Journal of Clinical Oncology . 1995
[9]  
Tumor angiogenesis and metastasis correlation in invasive breast carcinoma. Weidner N,Semple JP,Welch WR,et al. The New England Journal of Medicine . 1991
[10]  
Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing. Paavonen K,Puolakkainen P,Jussila L,et al. American Journal of Pathology . 2000